Patient P-02316

Synthetic patientMETA-24 · Day 177 · 65–74 · M · baseline S14Open companion preview

Therapy response

Improving

Tolerance

Stable

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

73%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S14
Day 47 NP-02 recommended — Dietary Support Protocol NP-02
Day 48 Patient accepted — Started NP-02 in the companion
Day 58 No meaningful change — Dietary Support Protocol NP-02
Day 71 GI-04 recommended — GI Support Protocol GI-04
Day 71 SC-12 recommended — Supportive Compound SC-12
Day 72 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 72 Patient accepted — Started GI-04 in the companion
Day 72 Patient accepted — Started SC-12 in the companion
Day 78 No meaningful change — Supportive Compound SC-12
Day 80 GI symptom burden −34% vs expected — GI Support Protocol GI-04
Day 86 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 72.

Primary contributors, last 14 days

GI instability-5
Inflammatory activity-3
Toxicity-3
Nutritional resilience+2

What helped?

Dietary Support Protocol NP-02Day 47
Result: no meaningful change
GI Support Protocol GI-04Day 71
Result: symptom burden −34%
Supportive Compound SC-12Day 71
Result: no meaningful change

LIFE OS recommendation

Monitoring Escalation ME-01

88%

probability of meaningful tolerance improvement

284 similar trajectories
100% showed improvement
median effect visible after 3 days

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 63 and rising
- WearableSleep 5.6 h, below personal baseline
Inflammatory signalling ↓70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 62
Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 48
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 40/100
- Daily logFibre intake low in recent food logs
Autonomic recovery ↑45
- WearableResting HR 85 bpm
- WearableShort sleep window

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Poor metabolizer
Higher exposure at standard dose
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2.7 · butyrate capacity 40/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 50 ms
Sleep: 5.4 h
Steps: 4,475
Resting HR: 87 bpm

Daily log: GI score 63, nutritional resilience 36, adherence 49.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02401	67%	S14	GI-04	improved	49
P-02516	61%	S14	SC-12	improved	51
P-02106	55%	S14	GI-04	improved	44
P-02348	54%	S14	GI-04	improved	49
P-02018	53%	S01	GI-04	improved	46
P-02694	53%	S14	—	—	56
P-02103	52%	S14	GI-04	improved	46
P-02504	51%	S14	GI-04	improved	52
P-02628	51%	S14	SC-12	improved	47
P-02670	50%	S14	SC-12	improved	45
P-02326	49%	S18	NP-02	improved	44
P-02535	49%	S14	SC-12	improved	50