Patient P-03449
Therapy response
Improving
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Favorable
Nutritional resilience
Improving
Discontinuation risk
41%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 68 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 69 DT-01 recommended — Dosing / Timing Recommendation DT-01
- Day 70 Patient accepted — Started DT-01 in the companion
- Day 75 GI symptom burden −16% vs expected — Dosing / Timing Recommendation DT-01
- Day 81 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 68.
Primary contributors, last 14 days
- GI instability+11
- Nutritional resilience+8
- Treatment adherence-5
- Toxicity+5
- Inflammatory activity+4
What helped?
- Dosing / Timing Recommendation DT-01Day 69Result: symptom burden −16%
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients.
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Autonomic recovery ↑65
- WearableResting HR 75 bpm
- Wearable3,878 steps/day
- WearableShort sleep window
- Mucosal barrier integrity ↓40
- DNAFUT2 non-secretor lowers mucosal fucosylation
- WearableSleep 6.1 h, below personal baseline
- Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
- Inflammatory signalling ↑20
- MicrobiomeBacteroides fragilis expansion
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 3.2 · butyrate capacity 61/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 68 ms
- Sleep
- 6.3 h
- Steps
- 5,229
- Resting HR
- 72 bpm
Daily log: GI score 27, nutritional resilience 64, adherence 94.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.