500 patients67,039 observations150 daysLIVE

500 trajectories across ONX-7

Trajectories

Synthetic demo data

All Strong responders · 120 Moderate responders · 110 Non-responders · 75 Early toxicity · 40 Late toxicity · 40 Delayed loss of response · 45 Resilient responder · 42 High response / high intolerance · 28

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-03323D148 · risk 96%

StableUnstableresp 48

P-03352D150 · risk 58%

ImprovingUnstableresp 59

P-03294D99 · risk 42%

UnstableDeterioratingresp 32

P-03287D146 · risk 33%

StableDeterioratingresp 55

P-03464D141 · risk 27%

DecliningDeterioratingresp 66

P-03273D138 · risk 22%

UnstableFavorableresp 37

P-03431D125 · risk 19%

FavorableDeterioratingresp 88

P-03318D149 · risk 17%

FavorableFavorableresp 65

P-03266D148 · risk 15%

FavorableFavorableresp 73

P-03315D90 · risk 13%

ImprovingFavorableresp 72

P-03062D142 · risk 10%

DecliningImprovingresp 44

P-03216D140 · risk 8%

UnstableImprovingresp 36