Patient P-02103
Therapy response
Stable
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
78%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S14
- Day 47 NP-02 recommended — Dietary Support Protocol NP-02
- Day 48 Patient accepted — Started NP-02 in the companion
- Day 58 GI symptom burden −17% vs expected — Dietary Support Protocol NP-02
- Day 64 Tolerance state changed — Unstable → Improving
- Day 75 GI-04 recommended — GI Support Protocol GI-04
- Day 76 Patient accepted — Started GI-04 in the companion
- Day 84 GI symptom burden −26% vs expected — GI Support Protocol GI-04
- Day 90 Tolerance state changed — Unstable → Improving
- Day 94 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 94.
Primary contributors, last 14 days
- Toxicity+7
- GI instability+5
- Inflammatory activity+3
- Treatment adherence-3
What helped?
- Dietary Support Protocol NP-02Day 47Result: symptom burden −17%
- GI Support Protocol GI-04Day 75Result: symptom burden −26%
LIFE OS recommendation
Monitoring Escalation ME-01
84%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 100% showed improvement
- median effect visible after 3 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 60 and rising
- WearableSleep 6.1 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 22/100
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 61
- Autonomic recovery ↓45
- WearableResting HR 80 bpm
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 49
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Normal metabolizerExpected exposure
- GLP1R rs6923761 AAltered receptor sensitivity
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 3.1 · butyrate capacity 22/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 52 ms
- Sleep
- 5.6 h
- Steps
- 5,882
- Resting HR
- 77 bpm
Daily log: GI score 60, nutritional resilience 40, adherence 51.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02018 | 49% | S01 | GI-04 | improved | 46 |
| P-02410 | 46% | S01 | GI-04 | improved | 55 |
| P-02054 | 33% | S01 | CR-01 | improved | 57 |
| P-02409 | 31% | S01 | SC-12 | no change | 54 |
| P-02041 | 23% | S01 | — | — | 27 |
| P-02307 | 23% | S01 | — | — | 55 |
| P-02598 | 23% | S01 | — | — | 53 |
| P-02087 | 22% | S01 | BR-03 | no change | 40 |
| P-02276 | 22% | S01 | — | — | 57 |
| P-02437 | 22% | S01 | — | — | 64 |
| P-02550 | 22% | S01 | — | — | 70 |
| P-02674 | 38% | S02 | NP-02 | improved | 48 |