Patient P-02149
Therapy response
Improving
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Deteriorating
Nutritional resilience
Unstable
Discontinuation risk
94%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S14
- Day 47 NP-02 recommended — Dietary Support Protocol NP-02
- Day 48 Patient accepted — Started NP-02 in the companion
- Day 58 GI symptom burden −21% vs expected — Dietary Support Protocol NP-02
- Day 64 Tolerance state changed — Unstable → Improving
- Day 66 SC-12 recommended — Supportive Compound SC-12
- Day 67 Patient accepted — Started SC-12 in the companion
- Day 72 GI-04 recommended — GI Support Protocol GI-04
- Day 73 Patient accepted — Started GI-04 in the companion
- Day 73 GI symptom burden −14% vs expected — Supportive Compound SC-12
- Day 79 Tolerance state changed — Unstable → Improving
- Day 80 ME-01 recommended — Monitoring Escalation ME-01
- Day 81 GI symptom burden −29% vs expected — GI Support Protocol GI-04
- Day 81 Patient accepted — Started ME-01 in the companion
- Day 84 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
- Day 85 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 87 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 85.
Primary contributors, last 14 days
- GI instability+18
- Nutritional resilience-12
- Inflammatory activity+8
- Toxicity+7
- Treatment adherence-2
What helped?
- Dietary Support Protocol NP-02Day 47Result: symptom burden −21%
- Supportive Compound SC-12Day 66Result: symptom burden −14%
- GI Support Protocol GI-04Day 72Result: symptom burden −29%
- Monitoring Escalation ME-01Day 80Result: deterioration detected before clinical escalation
LIFE OS recommendation
Clinician Review CR-01
85%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 100% showed improvement
- median effect visible after 5 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 64 and rising
- Inflammatory signalling ↑60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 56
- WearableHRV 22 ms, trending down
- Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 42
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 41/100
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↓45
- WearableResting HR 84 bpm
- Wearable1,731 steps/day
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 2.1 · butyrate capacity 41/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 23 ms
- Sleep
- 6.7 h
- Steps
- 2,698
- Resting HR
- 79 bpm
Daily log: GI score 64, nutritional resilience 34, adherence 48.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02142 | 57% | S14 | GI-04 | improved | 42 |
| P-02159 | 57% | S14 | GI-04 | improved | 47 |
| P-02236 | 48% | S14 | GI-04 | improved | 45 |
| P-02002 | 47% | S14 | GI-04 | improved | 47 |
| P-02445 | 47% | S09 | GI-04 | improved | 43 |
| P-02542 | 47% | S14 | NP-02 | improved | 44 |
| P-02108 | 46% | S14 | GI-04 | improved | 43 |
| P-02125 | 46% | S14 | GI-04 | improved | 55 |
| P-02185 | 46% | S14 | GI-04 | improved | 51 |
| P-02648 | 46% | S14 | SC-12 | improved | 47 |
| P-02018 | 45% | S01 | GI-04 | improved | 46 |
| P-02633 | 44% | S14 | NP-02 | improved | 48 |