Patient P-02236
Therapy response
Declining
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Stable
Nutritional resilience
Unstable
Discontinuation risk
73%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S14
- Day 71 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 72 GI-04 recommended — GI Support Protocol GI-04
- Day 73 Patient accepted — Started GI-04 in the companion
- Day 81 GI symptom burden −27% vs expected — GI Support Protocol GI-04
- Day 86 ME-01 recommended — Monitoring Escalation ME-01
- Day 87 Tolerance state changed — Unstable → Improving
- Day 87 Patient accepted — Started ME-01 in the companion
- Day 90 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
What changed?
Trajectory began diverging from predicted response on Day 71.
Primary contributors, last 14 days
- Treatment adherence-13
- Toxicity+5
What helped?
- GI Support Protocol GI-04Day 72Result: symptom burden −27%
- Monitoring Escalation ME-01Day 86Result: deterioration detected before clinical escalation
LIFE OS recommendation
Supportive Compound SC-12
63%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 69% showed improvement
- median effect visible after 6 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↓85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 55
- WearableHRV 24 ms, trending down
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 62 and rising
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 42/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↓25
- WearableResting HR 74 bpm
- Drug metabolism and exposure ↑20
- BloodToxicity index 48
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.6 · butyrate capacity 42/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 25 ms
- Sleep
- 6.8 h
- Steps
- 4,355
- Resting HR
- 75 bpm
Daily log: GI score 62, nutritional resilience 40, adherence 51.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02142 | 52% | S14 | GI-04 | improved | 42 |
| P-02149 | 48% | S14 | GI-04 | improved | 50 |
| P-02118 | 46% | S14 | GI-04 | improved | 47 |
| P-02244 | 46% | S14 | GI-04 | improved | 46 |
| P-02508 | 45% | S14 | ME-01 | improved | 51 |
| P-02125 | 44% | S14 | GI-04 | improved | 55 |
| P-02132 | 44% | S14 | SC-12 | improved | 40 |
| P-02159 | 44% | S14 | GI-04 | improved | 47 |
| P-02268 | 43% | S14 | GI-04 | improved | 43 |
| P-02381 | 43% | S14 | SC-12 | improved | 52 |
| P-02648 | 43% | S14 | SC-12 | improved | 47 |
| P-02018 | 42% | S01 | GI-04 | improved | 46 |