Patient P-02208
Therapy response
Declining
Tolerance
Unstable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S14
- Day 72 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 76 GI-04 recommended — GI Support Protocol GI-04
- Day 77 Patient declined — Not now
What changed?
Trajectory began diverging from predicted response on Day 72.
Primary contributors, last 14 days
- Nutritional resilience-8
- Inflammatory activity+5
- GI instability-4
- Toxicity+3
What helped?
- GI Support Protocol GI-04Day 76Declined by patient
LIFE OS recommendation
GI Support Protocol GI-04
92%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 88% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 69 and rising
- Inflammatory signalling ↑60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 70
- WearableHRV 22 ms, trending down
- Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 63
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 30/100
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑45
- WearableResting HR 73 bpm
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2 · butyrate capacity 30/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 24 ms
- Sleep
- 6.0 h
- Steps
- 5,003
- Resting HR
- 72 bpm
Daily log: GI score 69, nutritional resilience 27, adherence 40.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02610 | 53% | S14 | NP-02 | no change | 42 |
| P-02594 | 48% | S20 | — | — | 45 |
| P-02340 | 47% | S14 | NP-02 | no change | 46 |
| P-02511 | 47% | S04 | — | — | 51 |
| P-02582 | 45% | S14 | ME-01 | improved | 45 |
| P-02320 | 44% | S14 | NP-02 | improved | 50 |
| P-02514 | 44% | S05 | ME-01 | improved | 44 |
| P-02039 | 43% | S14 | — | — | 38 |
| P-02157 | 43% | S14 | ME-01 | improved | 55 |
| P-02571 | 42% | S11 | ME-01 | improved | 43 |
| P-02693 | 42% | S14 | ME-01 | improved | 41 |
| P-02132 | 41% | S14 | SC-12 | improved | 40 |