Patient P-02514

Synthetic patientMETA-24 · Day 173 · 55–64 · M · baseline S05Open companion preview

Therapy response

Declining

Tolerance

Unstable

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

96%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S05
Day 70 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 90 ME-01 recommended — Monitoring Escalation ME-01
Day 91 Patient accepted — Started ME-01 in the companion
Day 94 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 70.

Primary contributors, last 14 days

Toxicity+10
GI instability+6
Inflammatory activity+5
Nutritional resilience-5

What helped?

Monitoring Escalation ME-01Day 90
Result: deterioration detected before clinical escalation

LIFE OS recommendation

GI Support Protocol GI-04

92%

probability of meaningful tolerance improvement

284 similar trajectories
88% showed improvement
median effect visible after 8 days

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 72 and rising
- WearableSleep 5.1 h, below personal baseline
Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 26/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 67
- WearableHRV 37 ms, trending down
Autonomic recovery ↓40
- Wearable1,860 steps/day
- WearableShort sleep window
Drug metabolism and exposure ↑20
- BloodToxicity index 63

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.5 · butyrate capacity 26/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 39 ms
Sleep: 5.6 h
Steps: 1,795
Resting HR: 71 bpm

Daily log: GI score 72, nutritional resilience 30, adherence 40.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02340	53%	S14	NP-02	no change	46
P-02594	52%	S20	—	—	45
P-02546	51%	S20	NP-02	improved	40
P-02511	49%	S04	—	—	51
P-02039	48%	S14	—	—	38
P-02224	48%	S14	NP-02	no change	33
P-02157	47%	S14	ME-01	improved	55
P-02320	47%	S14	NP-02	improved	50
P-02348	47%	S14	GI-04	improved	49
P-02582	46%	S14	ME-01	improved	45
P-02614	46%	S14	—	—	39
P-02253	45%	S14	NP-02	no change	41