Patient P-02265
Therapy response
Favorable
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
69%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S07
- Day 117 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 122 GI-04 recommended — GI Support Protocol GI-04
- Day 123 Patient accepted — Started GI-04 in the companion
- Day 131 No meaningful change — GI Support Protocol GI-04
What changed?
Trajectory began diverging from predicted response on Day 117.
Primary contributors, last 14 days
- Inflammatory activity+17
- GI instability+11
- Nutritional resilience-11
- Toxicity+7
- Treatment adherence+4
What helped?
- GI Support Protocol GI-04Day 122Result: no meaningful change
LIFE OS recommendation
Monitoring Escalation ME-01
85%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 100% showed improvement
- median effect visible after 3 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 61
- WearableHRV 22 ms, trending down
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 40/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↓65
- WearableResting HR 83 bpm
- Wearable3,975 steps/day
- WearableShort sleep window
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 62 and rising
- WearableSleep 6.1 h, below personal baseline
- Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 49
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 3.1 · butyrate capacity 40/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 22 ms
- Sleep
- 6.1 h
- Steps
- 3,679
- Resting HR
- 81 bpm
Daily log: GI score 62, nutritional resilience 33, adherence 68.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02530 | 57% | S07 | — | — | 67 |
| P-02334 | 51% | S04 | GI-04 | improved | 66 |
| P-02433 | 49% | S07 | GI-04 | improved | 61 |
| P-02136 | 46% | S10 | — | — | 63 |
| P-02084 | 44% | S11 | GI-04 | no change | 58 |
| P-02029 | 43% | S18 | — | — | 56 |
| P-02631 | 43% | S17 | — | — | 58 |
| P-02591 | 42% | S13 | — | — | 68 |
| P-02595 | 40% | S02 | — | — | 53 |
| P-02046 | 39% | S10 | — | — | 55 |
| P-02078 | 39% | S04 | — | — | 56 |
| P-02054 | 38% | S01 | CR-01 | improved | 57 |