Patient P-02591
Therapy response
Improving
Tolerance
Improving
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Unstable
Discontinuation risk
55%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S13
- Day 10 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 10.
Primary contributors, last 14 days
- Toxicity-15
- GI instability-13
- Inflammatory activity-13
- Nutritional resilience+9
- Treatment adherence-4
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
61%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 89% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 54 and rising
- WearableSleep 6.1 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 38/100
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑45
- WearableResting HR 80 bpm
- WearableShort sleep window
- Inflammatory signalling ↓40
- BloodInflammatory load index 53
- WearableHRV 25 ms, trending down
- Drug metabolism and exposure ↑20
- BloodToxicity index 54
DNA
Fictional pharmacogenomic panel
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.7 · butyrate capacity 38/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 20 ms
- Sleep
- 6.2 h
- Steps
- 4,930
- Resting HR
- 82 bpm
Daily log: GI score 54, nutritional resilience 39, adherence 64.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02084 | 53% | S11 | GI-04 | no change | 58 |
| P-02631 | 50% | S17 | — | — | 58 |
| P-02034 | 48% | S18 | — | — | 61 |
| P-02530 | 48% | S07 | — | — | 67 |
| P-02029 | 44% | S18 | — | — | 56 |
| P-02136 | 44% | S10 | — | — | 63 |
| P-02025 | 43% | S15 | CR-01 | improved | 61 |
| P-02046 | 43% | S10 | — | — | 55 |
| P-02054 | 43% | S01 | CR-01 | improved | 57 |
| P-02250 | 43% | S04 | — | — | 64 |
| P-02151 | 42% | S04 | CR-01 | improved | 49 |
| P-02265 | 42% | S07 | GI-04 | no change | 67 |