Patient P-02298
Therapy response
Declining
Tolerance
Deteriorating
GI state
Stable
Inflammatory state
Favorable
Nutritional resilience
Stable
Discontinuation risk
45%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S14
- Day 66 SC-12 recommended — Supportive Compound SC-12
- Day 67 Patient declined — Not now
- Day 77 GI-04 recommended — GI Support Protocol GI-04
- Day 78 Patient accepted — Started GI-04 in the companion
- Day 86 GI symptom burden −32% vs expected — GI Support Protocol GI-04
- Day 92 Tolerance state changed — Unstable → Improving
What changed?
Trajectory is tracking the baseline prediction.
Primary contributors, last 14 days
- Toxicity+7
- Treatment adherence+5
- GI instability+4
- Nutritional resilience+2
What helped?
- Supportive Compound SC-12Day 66Declined by patient
- GI Support Protocol GI-04Day 77Result: symptom burden −32%
LIFE OS recommendation
Dosing / Timing Recommendation DT-01
51%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 75% showed improvement
- median effect visible after 5 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 32/100
- MicrobiomeF. prausnitzii depleted
- Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Inflammatory signalling ↓20
- MicrobiomeBacteroides fragilis expansion
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Normal metabolizerExpected exposure
- GLP1R rs6923761 AAltered receptor sensitivity
Microbiome
Shannon diversity 1.9 · butyrate capacity 32/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 57 ms
- Sleep
- 7.7 h
- Steps
- 5,929
- Resting HR
- 61 bpm
Daily log: GI score 40, nutritional resilience 53, adherence 93.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.