Patient P-02514
Synthetic patientMETA-24 · Day 173 · 55–64 · M · baseline S05Steering view · 3DOpen companion preview
Therapy response
Declining
Tolerance
Unstable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S05
- Day 70 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 90 ME-01 recommended — Monitoring Escalation ME-01
- Day 91 Patient accepted — Started ME-01 in the companion
- Day 94 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
What changed?
Trajectory began diverging from predicted response on Day 70.
Primary contributors, last 14 days
- Toxicity+10
- GI instability+6
- Inflammatory activity+5
- Nutritional resilience-5
What helped?
- Monitoring Escalation ME-01Day 90Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
92%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 88% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Active minutes
Wearable20 min
worsening · -5.5 vs previous 14 d
Sleep duration
Wearable5.1 h
stable · -0.2 vs previous 14 d
Energy level
Daily log0.7/10
worsening · -0.5 vs previous 14 d
Steps
Wearable1,860
worsening · -611 vs previous 14 d
GI burden
Companion72.3/100
worsening · +9.7 vs previous 14 d
Adherence
Companion40.4 %
stable · +1.0 vs previous 14 d
Sleep quality
Wearable11.6/100
worsening · -2.7 vs previous 14 d
Glucose, CGM daily mean
CGM148 mg/dL
stable · +3.4 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 21 from the failing basin, 78 from restoration.
Would help
- GI-04 GI Support Protocol76% improved among 66 similar · onset 8 d · confidence 95%
- NP-02 Dietary Support Protocol59% improved among 32 similar · onset 10 d · confidence 75%
- SC-12 Supportive Compound69% improved among 26 similar · onset 6 d · confidence 75%
- More proteinGI -2.9 next day on high-intake days · n 20
Would not help
- Keep fat lowGI +3.6 next day on high-intake days · n 21
- Keep ultra-processed lowGI +3.2 next day on high-intake days · n 20
- Keep histamine lowGI +2.1 next day on high-intake days · n 20
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+3.6detractor · 95%
- Ultra-processed food+3.2detractor · 95%
- Protein-2.9supporter · 95%
- Histamine load+2.1detractor · 71%
- Simple carbohydrates+1.5no signal · 52%
- Alcohol+1.2no signal · 44%
- Insoluble fibre+1.1no signal · 37%
- Caffeine+0.1no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 72 and rising
- WearableSleep 5.1 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 26/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 67
- WearableHRV 37 ms, trending down
- Autonomic recovery ↓40
- Wearable1,860 steps/day
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 63
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.5 · butyrate capacity 26/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 39 ms
- Sleep
- 5.6 h
- Steps
- 1,795
- Resting HR
- 71 bpm
Daily log: GI score 72, nutritional resilience 30, adherence 40.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02546 | 51% | S20 | NP-02 | improved | 40 |
| P-02157 | 47% | S14 | ME-01 | improved | 55 |
| P-02320 | 47% | S14 | NP-02 | improved | 50 |
| P-02348 | 47% | S14 | GI-04 | improved | 49 |
| P-02582 | 46% | S14 | ME-01 | improved | 45 |
| P-02571 | 45% | S11 | ME-01 | improved | 43 |
| P-02172 | 44% | S02 | ME-01 | improved | 36 |
| P-02372 | 44% | S14 | ME-01 | improved | 53 |
| P-02505 | 44% | S14 | NP-02 | improved | 45 |
| P-02628 | 44% | S14 | SC-12 | improved | 47 |
| P-02059 | 43% | S03 | SC-12 | improved | 41 |
| P-02297 | 43% | S02 | NP-02 | improved | 49 |