Patient P-02599
Therapy response
Improving
Tolerance
Favorable
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
55%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S14
- Day 15 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 22 HY-01 recommended — Hydration Protocol HY-01
- Day 23 Patient accepted — Started HY-01 in the companion
- Day 27 GI symptom burden −12% vs expected — Hydration Protocol HY-01
- Day 33 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 15.
Primary contributors, last 14 days
- GI instability+20
- Nutritional resilience-9
- Inflammatory activity+8
- Treatment adherence+6
- Toxicity-2
What helped?
- Hydration Protocol HY-01Day 22Result: symptom burden −12%
LIFE OS recommendation
Clinician Review CR-01
81%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 100% showed improvement
- median effect visible after 5 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↑60
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- WearableHRV 35 ms, trending down
- Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
- Butyrate / short-chain fatty acid production ↓35
- MicrobiomeButyrate capacity 39/100
- Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
- Autonomic recovery ↓25
- WearableResting HR 75 bpm
DNA
Fictional pharmacogenomic panel
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 2.4 · butyrate capacity 39/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 41 ms
- Sleep
- 7.1 h
- Steps
- 6,946
- Resting HR
- 73 bpm
Daily log: GI score 35, nutritional resilience 55, adherence 95.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02218 | 42% | S01 | DT-01 | improved | 61 |
| P-02276 | 41% | S01 | — | — | 57 |
| P-02598 | 40% | S01 | — | — | 53 |
| P-02307 | 39% | S01 | — | — | 55 |
| P-02568 | 38% | S01 | — | — | 51 |
| P-02087 | 36% | S01 | BR-03 | no change | 40 |
| P-02354 | 35% | S01 | CR-01 | improved | 78 |
| P-02620 | 35% | S01 | HY-01 | improved | 64 |
| P-02375 | 34% | S01 | — | — | 44 |
| P-02437 | 34% | S01 | — | — | 64 |
| P-02424 | 33% | S01 | — | — | 62 |
| P-02522 | 33% | S01 | BR-03 | no change | 40 |