GI-04 · GI Support Protocol
Nutritional protocolSynthetic demo dataTarget state: GI instability · onset 8 d · prior: symptom −31%, persistence +17%, tolerance +22%Simulate on eligible patients
What it is
A 14-day gut-support protocol delivered through the companion for patients whose GI burden is rising ahead of the model: structured low-residue nutrition on dosing days, timed hydration, a barrier-support supplement bundle and a one-tap daily GI check-in.
How it works
Reduces luminal load and osmotic stress around the dose (low-residue, small meals), keeps stool volume and electrolytes stable (timed hydration), supports the epithelial barrier and butyrate producers (soluble fibre off dosing days, butyrate precursor), and makes escalation early by measuring GI daily.
What the patient does, day by day
| Day 1 | ✓ | Start: read why The companion explains the rising GI pattern and shows the 14-day plan; the patient confirms. |
| Dosing days | 🍽 | Low-residue meals White rice, peeled vegetables, lean protein; no raw fibre, no fried food 48 h around the dose. |
| Dosing days | 💊 | Electrolyte sachet 1 sachet in 500 ml water in the morning and after each loose stool. |
| Every day | 🍽 | Six small meals Replace three meals with six smaller ones on symptomatic days. |
| Every day | 💊 | Butyrate precursor (demo) 2 capsules with dinner; first effect expected after ~10 days. |
| Off-dosing days | 🍽 | Gradual soluble fibre Oats or psyllium, +5 g per week to 20 g. |
| Every evening | ✓ | One-tap GI score A 0–100 GI score; the nurse is alerted if ≥ 60 for 3 days. |
| Day 14 | 🏥 | Outcome read LIFE OS compares observed vs predicted ΔGI and writes the response into the trajectory. |
Delivery
- Owner
- Companion
- Channel
- Daily content in the NostraAI companion; nurse alerted by threshold
- Duration
- 14 days
- Touchpoints
- Every morning (plan for the day) and evening (GI check-in)
- Cost
- ≈ €180 per patient (supplements + nurse time)
Monitoring
- · Daily GI score
- · Stool frequency (companion)
- · Resting HR and sleep (wearable)
- · Weight weekly
Stop rules
- · GI ≥ 60 for 3 consecutive days → nurse call within 24 h
- · Fever or blood in stool → investigator, protocol suspended
- · Weight −3 % in 2 weeks → dietitian review
Contraindications
- · Active bowel obstruction
- · Known intolerance to the supplement bundle
- · Patients on enteral feeding (different protocol)
Evidence in NBL-101
130 accepted · 65% improved · mean effect −17%By biology segment
| Poor metabolizer | n 29 | 72% |
| Low microbial diversity | n 102 | 69% |
| IL6 high-expression variant | n 69 | 64% |
| Cluster EC-03 (high response / high intolerance) | n 115 | 62% |
| FUT2 non-secretor | n 82 | 61% |
| Low butyrate capacity | n 83 | 61% |
| Baseline state S14 | n 77 | 60% |
| Adherence < 60% | n 111 | 60% |
Works best when
- · Started within 5 days of divergence
- · Baseline S14 / EC-03 phenotype
- · IL6 high-expression variant
- · Adherence ≥ 70 %
Works poorly when
- · GI burden already ≥ 75 (needs clinical escalation first)
- · Adherence < 55 %
- · Poor metabolizers with toxicity ≥ 55
What the model has learned about it
No learned rule yet for GI-04. Run learning after campaign results.
Campaigns using it
None yet. 232 patients look eligible right now.