HY-01 · Hydration Protocol
Hydration protocolSynthetic demo dataTarget state: GI instability · onset 4 d · prior: symptom −14%, persistence +6%, tolerance +8%Simulate for P-01432
For P-01432
Eligible at 64% confidence. Among the 284 most similar trajectories: 2 accepted, 100% improved, mean effect −16%.
What it is
A 10-day hydration plan timed around dosing days: electrolyte solution schedule, fluid targets and a wearable-based dehydration alert.
How it works
Prevents the volume and electrolyte losses that turn moderate GI symptoms into toxicity and fatigue; keeps resting HR stable.
What the patient does, day by day
| Dosing days | 💊 | Electrolyte solution 500 ml before the dose, 500 ml after, 250 ml after each loose stool. |
| Every day | ✓ | Fluid target 35 ml/kg; tracked by taps in the companion. |
| Every day | ✓ | Wearable check Alert if resting HR +8 bpm over baseline for 2 days. |
Delivery
- Owner
- Companion
- Channel
- Reminders in the companion; nurse alert on wearable threshold
- Duration
- 10 days
- Touchpoints
- 3 reminders per day on dosing days
- Cost
- ≈ €40 per patient
Monitoring
- · Resting HR
- · Stool frequency
- · Fluid taps
Stop rules
- · Resting HR +12 bpm or dizziness → nurse call
Contraindications
- · Heart failure with fluid restriction
- · Renal impairment requiring restriction
Evidence in NBL-101
12 accepted · 67% improved · mean effect −14%By biology segment
| FUT2 non-secretor | n 4 | 75% |
| Low microbial diversity | n 10 | 70% |
| Low butyrate capacity | n 10 | 60% |
| IL6 high-expression variant | n 4 | 50% |
| Poor metabolizer | n 4 | 50% |
By trajectory cluster
| ET | n 9 | 89% |
Works best when
- · Diarrhoea-dominant GI pattern
- · Early in the course
Works poorly when
- · Nausea-dominant pattern
- · Inflammation-led deterioration
What the model has learned about it
No learned rule yet for HY-01. Run learning after campaign results.
Campaigns using it
None yet. 232 patients look eligible right now.