Patient P-01371
Therapy response
Favorable
Tolerance
Improving
GI state
Stable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
47%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S06
- Day 28 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 82 CR-01 recommended — Clinician Review CR-01
- Day 83 Patient accepted — Started CR-01 in the companion
- Day 88 Deterioration detected before clinical escalation — Clinician Review CR-01
What changed?
Trajectory began diverging from predicted response on Day 28.
Primary contributors, last 14 days
- Treatment adherence-10
- Toxicity-4
- GI instability-3
- Nutritional resilience+2
What helped?
- Clinician Review CR-01Day 82Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
58%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 93% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 34/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Mucosal barrier integrity ↓50
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 49 and rising
- Autonomic recovery ↑40
- Wearable3,638 steps/day
- WearableShort sleep window
- Inflammatory signalling ↑25
- BloodInflammatory load index 58
- Drug metabolism and exposure ↑20
- BloodToxicity index 41
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 2.9 · butyrate capacity 34/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 38 ms
- Sleep
- 5.5 h
- Steps
- 2,967
- Resting HR
- 66 bpm
Daily log: GI score 49, nutritional resilience 40, adherence 68.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01699 | 48% | S04 | GI-04 | improved | 69 |
| P-01459 | 44% | S02 | — | — | 51 |
| P-01696 | 43% | S20 | CR-01 | improved | 59 |
| P-01768 | 43% | S20 | — | — | 53 |
| P-01388 | 42% | S17 | CR-01 | improved | 59 |
| P-01769 | 42% | S20 | — | — | 60 |
| P-01725 | 41% | S18 | GI-04 | no change | 56 |
| P-01795 | 41% | S06 | — | — | 61 |
| P-01708 | 40% | S07 | CR-01 | improved | 59 |
| P-01715 | 40% | S05 | — | — | 56 |
| P-01600 | 39% | S06 | — | — | 51 |
| P-01623 | 39% | S16 | — | — | 52 |