Patient P-01371

Synthetic patientNBL-101 · Day 107 · 25–34 · F · baseline S06Steering view · 3D Open companion preview

Therapy response

Favorable

Tolerance

Improving

GI state

Stable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

47%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S06
Day 28 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 82 CR-01 recommended — Clinician Review CR-01
Day 83 Patient accepted — Started CR-01 in the companion
Day 88 Deterioration detected before clinical escalation — Clinician Review CR-01

What changed?

Trajectory began diverging from predicted response on Day 28.

Primary contributors, last 14 days

Treatment adherence-10
Toxicity-4
GI instability-3
Nutritional resilience+2

What helped?

Clinician Review CR-01Day 82
Result: deterioration detected before clinical escalation

LIFE OS recommendation

GI Support Protocol GI-04

58%

probability of meaningful tolerance improvement

284 similar trajectories
93% showed improvement
median effect visible after 8 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

49.4/100

worsening · +3.5 vs previous 14 d

Toxicity

Blood

40.6/100

worsening · +13.9 vs previous 14 d

Sleep quality

Wearable

36.1/100

improving · +1.1 vs previous 14 d

Energy level

Daily log

3.2/10

worsening · -0.6 vs previous 14 d

Stress level

Daily log

5.4/10

worsening · +0.6 vs previous 14 d

Steps

Wearable

3,638

worsening · -555 vs previous 14 d

Adherence

Companion

68.1 %

worsening · -15.0 vs previous 14 d

This trajectory is doing well — what to keep, what to watch

Steering view →

Heading towards restoration · 44 from the failing basin, 50 from restoration.

Good elements to keep

Clinician Review CR-01
intervention · steering +24.8
Daily walks resumed
perturbation · steering +3.3

Main detractors to watch

Low butyrate capacity
hidden · steering -17.5
FUT2 non-secretor
hidden · steering -10.6
Rapid metabolizer
hidden · steering -8
Low microbial diversity
hidden · steering -7.7
Simple carbohydrates
detractor · GI +3.3 next day
Histamine load
detractor · GI +3.1 next day

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Simple carbohydrates
+3.3detractor · 95%
Histamine load
+3.1detractor · 95%
Dietary fat load
+3detractor · 95%
Spicy / capsaicin
-1.3no signal · 33%
Insoluble fibre
+0.4no signal · 15%
Alcohol
0no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 34/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Mucosal barrier integrity ↓50
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 49 and rising
Autonomic recovery ↑40
- Wearable3,638 steps/day
- WearableShort sleep window
Inflammatory signalling ↑25
- BloodInflammatory load index 58
Drug metabolism and exposure ↑20
- BloodToxicity index 41

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Rapid metabolizer
Expected exposure

Microbiome

Shannon diversity 2.9 · butyrate capacity 34/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 38 ms
Sleep: 5.5 h
Steps: 2,967
Resting HR: 66 bpm

Daily log: GI score 49, nutritional resilience 40, adherence 68.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01804	27%	S19	AD-05	improved	61
P-01689	25%	S13	BR-03	no change	50
P-01696	43%	S20	CR-01	improved	59
P-01388	42%	S17	CR-01	improved	59
P-01708	40%	S07	CR-01	improved	59
P-01442	38%	S13	CR-01	improved	61
P-01835	38%	S17	CR-01	improved	56
P-01877	35%	S01	CR-01	improved	67
P-01430	27%	S05	CR-01	improved	54
P-01342	27%	S11	DT-01	improved	48
P-01767	27%	S14	DT-01	no change	63
P-01346	24%	S12	DT-01	improved	52