Patient P-01442

Synthetic patientNBL-101 · Day 110 · 35–44 · M · baseline S13Steering view · 3D Open companion preview

Therapy response

Improving

Tolerance

Deteriorating

GI state

Improving

Inflammatory state

Stable

Nutritional resilience

Improving

Discontinuation risk

47%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S13
Day 82 CR-01 recommended — Clinician Review CR-01
Day 83 Patient accepted — Started CR-01 in the companion
Day 85 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 88 Deterioration detected before clinical escalation — Clinician Review CR-01

What changed?

Trajectory began diverging from predicted response on Day 85.

Primary contributors, last 14 days

GI instability-15
Toxicity+13
Nutritional resilience+12
Treatment adherence-8

What helped?

Clinician Review CR-01Day 82
Result: deterioration detected before clinical escalation

LIFE OS recommendation

Dietary Support Protocol NP-02

68%

probability of meaningful tolerance improvement

284 similar trajectories
86% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

40.1/100

worsening · +11.8 vs previous 14 d

Toxicity

Blood

56/100

worsening · +9.1 vs previous 14 d

Sleep quality

Wearable

31/100

worsening · -6.1 vs previous 14 d

Energy level

Daily log

3.9/10

worsening · -0.9 vs previous 14 d

Stress level

Daily log

6.2/10

worsening · +0.6 vs previous 14 d

Steps

Wearable

3,967

worsening · -866 vs previous 14 d

Adherence

Companion

67.8 %

worsening · -12.3 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards restoration · 47 from the failing basin, 44 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 57 similar · onset 3 d · confidence 65%
NP-02 Dietary Support Protocol
70% improved among 54 similar · onset 10 d · confidence 65%
SC-12 Supportive Compound
82% improved among 44 similar · onset 6 d · confidence 65%

Would not help

Keep histamine low
GI +6.6 next day on high-intake days · n 28
Keep fat low
GI +5 next day on high-intake days · n 21
Keep alcohol low
GI +3.7 next day on high-intake days · n 20

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+6.6detractor · 95%
Dietary fat load
+5detractor · 95%
Alcohol
+3.7detractor · 81%
Simple carbohydrates
+3.4detractor · 72%
Spicy / capsaicin
-2.9no signal · 43%
Insoluble fibre
+0.5no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 56
- WearableHRV 20 ms, trending down
Butyrate / short-chain fatty acid production ↓35
- MicrobiomeButyrate capacity 41/100
Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation
Drug metabolism and exposure ↑20
- BloodToxicity index 56
Autonomic recovery ↑20
- Wearable3,967 steps/day

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 1.9 · butyrate capacity 41/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 22 ms
Sleep: 7.1 h
Steps: 3,561
Resting HR: 65 bpm

Daily log: GI score 40, nutritional resilience 50, adherence 68.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01310	37%	S01	—	—	57
P-01877	33%	S01	CR-01	improved	67
P-01688	30%	S01	GI-04	improved	40
P-01327	27%	S01	GI-04	improved	56
P-01604	27%	S01	—	—	71
P-01823	26%	S01	—	—	57
P-01821	25%	S01	—	—	58
P-01455	23%	S01	GI-04	improved	61
P-01459	38%	S02	—	—	51
P-01635	32%	S02	GI-04	improved	49
P-01452	30%	S02	GI-04	improved	46
P-01499	28%	S02	—	—	65