Patient P-01452

Synthetic patientNBL-101 · Day 90 · 55–64 · M · baseline S02Steering view · 3D Open companion preview

Therapy response

Declining

Tolerance

Stable

GI state

Stable

Inflammatory state

Stable

Nutritional resilience

Unstable

Discontinuation risk

61%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S02
Day 49 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 55 GI-04 recommended — GI Support Protocol GI-04
Day 56 Patient accepted — Started GI-04 in the companion
Day 64 GI symptom burden −29% vs expected — GI Support Protocol GI-04
Day 70 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 49.

Primary contributors, last 14 days

Treatment adherence-7
Nutritional resilience-5
GI instability+2
Toxicity+2

What helped?

GI Support Protocol GI-04Day 55
Result: symptom burden −29%

LIFE OS recommendation

Dietary Support Protocol NP-02

54%

probability of meaningful tolerance improvement

284 similar trajectories
66% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

52.9/100

improving · -3.3 vs previous 14 d

Toxicity

Blood

49/100

worsening · +5.0 vs previous 14 d

Sleep quality

Wearable

29.6/100

improving · +2.6 vs previous 14 d

Energy level

Daily log

3/10

stable · 0.0 vs previous 14 d

Stress level

Daily log

6.4/10

stable · -0.1 vs previous 14 d

Steps

Wearable

4,341

worsening · -280 vs previous 14 d

Adherence

Companion

49.3 %

worsening · -22.1 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 32 from the failing basin, 55 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 77 similar · onset 3 d · confidence 64%
NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 64%
SC-12 Supportive Compound
76% improved among 51 similar · onset 6 d · confidence 64%

Would not help

Keep fat low
GI +5.1 next day on high-intake days · n 20
Keep simple carbs low
GI +4 next day on high-intake days · n 19

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+5.1detractor · 95%
Simple carbohydrates
+4detractor · 95%
Spicy / capsaicin
+1.9no signal · 40%
Insoluble fibre
-1.5no signal · 38%
Alcohol
-1.3no signal · 27%
Histamine load
+1no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 23/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 53 and rising
- WearableSleep 5.9 h, below personal baseline
Inflammatory signalling ↑50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 51
Autonomic recovery ↓45
- WearableResting HR 81 bpm
- WearableShort sleep window
Drug metabolism and exposure ↑20
- BloodToxicity index 49

DNA

Fictional pharmacogenomic panel

IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2.1 · butyrate capacity 23/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 44 ms
Sleep: 5.3 h
Steps: 4,623
Resting HR: 83 bpm

Daily log: GI score 53, nutritional resilience 39, adherence 49.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01604	22%	S01	—	—	71
P-01386	22%	S13	—	—	70
P-01352	22%	S20	—	—	70
P-01750	23%	S16	—	—	69
P-01699	31%	S04	GI-04	improved	69
P-01508	23%	S18	—	—	68
P-01509	23%	S17	—	—	68
P-01877	29%	S01	CR-01	improved	67
P-01515	22%	S16	—	—	66
P-01629	23%	S19	—	—	66
P-01714	28%	S14	GI-04	improved	66
P-01858	31%	S14	NP-02	improved	65