Patient P-01458
Synthetic patientNBL-101 · Day 117 · 55–64 · M · baseline S14Steering view · 3DOpen companion preview
Therapy response
Stable
Tolerance
Improving
GI state
Deteriorating
Inflammatory state
Stable
Nutritional resilience
Declining
Discontinuation risk
75%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 46 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 59 GI-04 recommended — GI Support Protocol GI-04
- Day 60 Patient accepted — Started GI-04 in the companion
- Day 68 GI symptom burden −38% vs expected — GI Support Protocol GI-04
- Day 74 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 46.
Primary contributors, last 14 days
- GI instability+12
- Toxicity-9
- Nutritional resilience-4
- Treatment adherence-3
What helped?
- GI Support Protocol GI-04Day 59Result: symptom burden −38%
LIFE OS recommendation
Dietary Support Protocol NP-02
63%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 66% showed improvement
- median effect visible after 10 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion49.5/100
stable · +1.7 vs previous 14 d
Toxicity
Blood37.1/100
worsening · +5.7 vs previous 14 d
Sleep quality
Wearable35.8/100
stable · +0.5 vs previous 14 d
Energy level
Daily log3.5/10
worsening · -0.4 vs previous 14 d
Stress level
Daily log5.7/10
worsening · +0.4 vs previous 14 d
Steps
Wearable3,188
stable · +43 vs previous 14 d
Adherence
Companion52.1 %
stable · +1.7 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 35 from the failing basin, 52 from restoration.
Would help
Would not help
- Keep histamine lowGI +4.2 next day on high-intake days · n 17
- Keep simple carbs lowGI +3.6 next day on high-intake days · n 14
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+4.2detractor · 95%
- Simple carbohydrates+3.6detractor · 86%
- Insoluble fibre+1.6no signal · 27%
- Spicy / capsaicin+1.3no signal · 27%
- Dietary fat load+1no signal · 22%
- Alcohol+0.6no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Drug metabolism and exposure ↑75
- DNACYP2D6 poor metabolizer → higher exposure
- DNADPYD *2A → slower clearance
- Mucosal barrier integrity ↓50
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 50 and rising
- Butyrate / short-chain fatty acid production ↓45
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑45
- WearableResting HR 74 bpm
- Wearable3,188 steps/day
- Inflammatory signalling ↓25
- BloodInflammatory load index 46
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 2.8 · butyrate capacity 46/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 45 ms
- Sleep
- 6.9 h
- Steps
- 2,419
- Resting HR
- 76 bpm
Daily log: GI score 50, nutritional resilience 48, adherence 52.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01604 | 25% | S01 | — | — | 71 |
| P-01386 | 25% | S13 | — | — | 70 |
| P-01352 | 25% | S20 | — | — | 70 |
| P-01750 | 26% | S16 | — | — | 69 |
| P-01699 | 30% | S04 | GI-04 | improved | 69 |
| P-01508 | 25% | S18 | — | — | 68 |
| P-01509 | 27% | S17 | — | — | 68 |
| P-01817 | 26% | S14 | — | — | 67 |
| P-01877 | 27% | S01 | CR-01 | improved | 67 |
| P-01629 | 26% | S19 | — | — | 66 |
| P-01714 | 35% | S14 | GI-04 | improved | 66 |
| P-01858 | 39% | S14 | NP-02 | improved | 65 |