DeepGene damage signature

SyntheticSynthetic demo data2 samples: baseline day 0 · retest day 90

Damage score · retest day 90

32/100

vs baseline (day 0)

2 improved · 3 worsened

synthetic signature · consistent with this patient's biology

3 opportunists above range: Escherichia coli, Enterococcus faecium, Clostridioides difficile
2 keystone species absent
3 resistance genes

Pathogens / opportunists3/5

↑ from 2

Keystone species2/8

↑ from 1

Diversity0/2

↓ from 1

Metabolic modules0/4

Vitamin synthesis1/7

Oral translocation1/1

Host DNA0/1

Tissue recycling0/1

Central mechanisms0/2

Virulence factors2/2

↑ from 1

Antibiotic resistance genes3/3

↓ from 4

Genetic predisposition2/2

Opportunists above range

Escherichia coli 9.78% AR

Enterococcus faecium 4.89% AR

Clostridioides difficile 0.978% AR

Keystone species absent

Akkermansia muciniphila, Bifidobacterium longum

Capacity

Shannon 3.1 · butyrate 789 CPM · SCFA 1188

1 vitamins below

Host & mechanisms

tissue recycling 30/100

oral translocation 2.25% AR

3 resistance genes · 2 virulence factors

Import a sample

day Import DeepGene CSV

A baseline sample re-initializes this patient's microbiome, pathways and predispositions from the measurement; a retest adds a comparison and updates them. Every theory, steering gain and dietary sensitivity downstream is then conditioned on the measured signature.

All elements · baseline → latest

Value, status vs the expected range, and the implication on health. Changes coloured: green improved / resolved, red worsened / new.

Pathogens / opportunists · 5

Escherichia coli	9.472 % AR · above range	9.78 % AR · above range	expected <= 1%	In excess raises LPS load and zonulin release, opening tight junctions.
Klebsiella pneumoniae	0.173 % AR · in range	0.113 % AR · in range	expected <= 0.3%	Opportunist above range; relevant after antibiotics and in inflammation.
Enterococcus faecium	0.171 % AR · in range	4.89 % AR · above range(worsened)	expected <= 0.5%	Opportunist above range; relevant after antibiotics and in inflammation.
Streptococcus gallolyticus	0.005 % AR · in range	0.067 % AR · in range	expected <= 0.1%	Opportunist above range; relevant after antibiotics and in inflammation.
Clostridioides difficile	0.947 % AR · above range	0.978 % AR · above range	expected <= 0.1%	Opportunist above range; relevant after antibiotics and in inflammation.

Keystone species · 8

Akkermansia muciniphila	0 % AR · absent	0 % AR · absent	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Bifidobacterium longum	0.33 % AR · in range	0 % AR · absent(worsened)	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Butyricicoccus pullicaecorum	0.33 % AR · in range	0.64 % AR · in range	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Eubacterium rectale	0.85 % AR · in range	0.3 % AR · in range	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Faecalibacterium prausnitzii	1.1 % AR · in range	0.43 % AR · in range	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Lactobacillus species	0.16 % AR · in range	0.51 % AR · in range	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Roseburia intestinalis	1.2 % AR · in range	0.62 % AR · in range	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Ruminococcus bromii	1.44 % AR · in range	0.06 % AR · in range	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.

Diversity · 2

indice Shannon	2.97 · below range	3.1 · in range(improved)	expected >= 3.0	Low diversity: fewer reserve metabolic routes, slower recovery after perturbation.
numar de specii detectate	140 specii · in range	149 specii · in range	expected >= 100	Species count below reference.

Metabolic modules · 4

Butyrate production	798 CPM · in range	789 CPM · in range	expected 255.83-1089.91 CPM	Butyrate is the main colonocyte fuel and barrier signal.
Short Chain Fatty Acid Production	1219 CPM · in range	1188 CPM · in range	expected 535.03-1572.59 CPM	Total SCFA capacity.
GABA production	430 CPM · in range	437 CPM · in range	expected 87.31-766.53 CPM	Gut–brain axis capacity.
H2S production (sulfate reduction)	100 CPM · in range	105 CPM · in range	expected banda de referinta	Hydrogen sulfide above band irritates the mucosa.

Vitamin synthesis · 7

Vitamin B1 - Thiamin	162 CPM · below range	371 CPM · below range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B2 - Riboflavin	3793 CPM · in range	4237 CPM · in range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B5 - Pantothenic acid	3997 CPM · in range	2828 CPM · in range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B6 - Pyridoxine	4278 CPM · in range	3273 CPM · in range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B7 - Biotin	4292 CPM · in range	2531 CPM · in range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B9 - Folate	3471 CPM · in range	3653 CPM · in range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B12 - Cobalamin	3450 CPM · in range	4482 CPM · in range	expected 2000-5000 CPM	Microbial synthesis capacity.

Oral translocation · 1

Translocare orala (indice)

2.18 % AR · above range

2.25 % AR · above range

expected <= 2%

Oral taxa in stool: reduced gastric barrier or dysbiosis.

Host DNA · 1

fragmentare mixta

164 pb · in range

159 pb · in range

expected 150-170 pb

Host cell-free DNA fragmentation pattern.

Tissue recycling · 1

indice de reciclare tisulara

35 /100 · in range

30 /100 · in range

expected < 35

Epithelial turnover.

Central mechanisms · 2

molecular_mimicry	54 /100 · in range	49 /100 · in range	expected < 65	Cross-reactive antigen load.
estrobolome	56 /100 · in range	60 /100 · in range	expected < 65	Estrogen-recycling capacity.

Virulence factors · 2

fimD outer membrane usher	27 potriviri/M · present	86 potriviri/M · present	expected absent	Virulence factor detected.
chuA heme/hemoglobin receptor	—	74 potriviri/M · present(new)	expected absent	Virulence factor detected.

Antibiotic resistance genes · 4

sul1	2.8 citiri/M · present	4.4 citiri/M · present	expected nedetectat	Resistance gene detected.
sul2	6.6 citiri/M · present	5.2 citiri/M · present	expected nedetectat	Resistance gene detected.
tet(O/M/O)	1.7 citiri/M · present	1 citiri/M · present	expected nedetectat	Resistance gene detected.
Ecol_ampC_BLA	3.9 citiri/M · present	resolved(resolved)	expected nedetectat	Resistance gene detected.

Genetic predisposition · 2

DPYD	1.98 OR · risk variant	3.14 OR · risk variant	expected reference genotype	Slower drug clearance
CYP2D6	2.34 OR · risk variant	1.61 OR · risk variant	expected reference genotype	Expected exposure