Patient P-01488

Synthetic patientNBL-101 · Day 98 · 35–44 · F · baseline S12Steering view · 3D Open companion preview

Therapy response

Improving

Tolerance

Stable

GI state

Improving

Inflammatory state

Stable

Nutritional resilience

Unstable

Discontinuation risk

52%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S12
Day 48 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 59 GI-04 recommended — GI Support Protocol GI-04
Day 60 Patient accepted — Started GI-04 in the companion
Day 68 GI symptom burden −18% vs expected — GI Support Protocol GI-04
Day 69 ME-01 recommended — Monitoring Escalation ME-01
Day 70 Patient accepted — Started ME-01 in the companion
Day 73 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
Day 74 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 48.

Primary contributors, last 14 days

GI instability-12
Inflammatory activity-4
Nutritional resilience+4

What helped?

GI Support Protocol GI-04Day 59
Result: symptom burden −18%
Monitoring Escalation ME-01Day 69
Result: deterioration detected before clinical escalation

LIFE OS recommendation

Dietary Support Protocol NP-02

56%

probability of meaningful tolerance improvement

284 similar trajectories
66% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

42.2/100

improving · -2.3 vs previous 14 d

Toxicity

Blood

51.9/100

worsening · +6.5 vs previous 14 d

Sleep quality

Wearable

45.5/100

improving · +5.3 vs previous 14 d

Energy level

Daily log

3.7/10

stable · -0.0 vs previous 14 d

Stress level

Daily log

5.9/10

stable · -0.1 vs previous 14 d

Steps

Wearable

5,228

stable · -93 vs previous 14 d

Adherence

Companion

52.5 %

worsening · -2.8 vs previous 14 d

This trajectory is doing well — what to keep, what to watch

Steering view →

Heading towards restoration · 40 from the failing basin, 48 from restoration.

Good elements to keep

GI Support Protocol GI-04
intervention · steering +23.9
Monitoring Escalation ME-01
intervention · steering +3.5
Daily walks resumed
perturbation · steering +3.3

Main detractors to watch

Low butyrate capacity
hidden · steering -17.5
FUT2 non-secretor
hidden · steering -10.6
Low microbial diversity
hidden · steering -7.7
Dietary fat load
perturbation · steering -5.6
Dietary fat load
detractor · GI +3 next day
Histamine load
detractor · GI +2.6 next day

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+3detractor · 95%
Histamine load
+2.6detractor · 95%
Simple carbohydrates
+1no signal · 40%
Spicy / capsaicin
+0.5no signal · 15%
Insoluble fibre
+0.4no signal · 15%
Alcohol
-0.4no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 33/100
- Daily logFibre intake low in recent food logs
Autonomic recovery ↑45
- WearableResting HR 82 bpm
- WearableShort sleep window
Inflammatory signalling ↓25
- BloodInflammatory load index 52
Drug metabolism and exposure ↑20
- BloodToxicity index 52

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.9 · butyrate capacity 33/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 54 ms
Sleep: 5.8 h
Steps: 4,213
Resting HR: 83 bpm

Daily log: GI score 42, nutritional resilience 40, adherence 53.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01494	48%	S14	GI-04	improved	42
P-01891	48%	S14	SC-12	improved	41
P-01403	47%	S14	GI-04	improved	49
P-01547	47%	S13	GI-04	improved	50
P-01360	44%	S14	GI-04	improved	52
P-01413	44%	S14	GI-04	improved	44
P-01423	43%	S19	GI-04	improved	44
P-01452	43%	S02	GI-04	improved	46
P-01675	43%	S14	NP-02	improved	38
P-01782	43%	S14	NP-02	no change	48
P-01389	42%	S14	SC-12	improved	46
P-01539	42%	S14	GI-04	improved	43