Patient P-01518

Synthetic patientNBL-101 · Day 108 · 75+ · M · baseline S14Steering view · 3D Open companion preview

Therapy response

Unstable

Tolerance

Stable

GI state

Improving

Inflammatory state

Stable

Nutritional resilience

Stable

Discontinuation risk

59%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 45 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 54 GI-04 recommended — GI Support Protocol GI-04
Day 55 Patient accepted — Started GI-04 in the companion
Day 63 GI symptom burden −34% vs expected — GI Support Protocol GI-04
Day 68 ME-01 recommended — Monitoring Escalation ME-01
Day 69 Tolerance state changed — Unstable → Improving
Day 69 Patient accepted — Started ME-01 in the companion
Day 72 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 45.

Primary contributors, last 14 days

GI instability-5
Nutritional resilience+3
Toxicity+3
Inflammatory activity-2

What helped?

GI Support Protocol GI-04Day 54
Result: symptom burden −34%
Monitoring Escalation ME-01Day 68
Result: deterioration detected before clinical escalation

LIFE OS recommendation

Dietary Support Protocol NP-02

52%

probability of meaningful tolerance improvement

284 similar trajectories
66% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

37.8/100

improving · -4.9 vs previous 14 d

Toxicity

Blood

44.1/100

improving · -6.2 vs previous 14 d

Sleep quality

Wearable

29.5/100

stable · -0.0 vs previous 14 d

Energy level

Daily log

3.1/10

improving · +0.3 vs previous 14 d

Stress level

Daily log

6.2/10

improving · -0.5 vs previous 14 d

Steps

Wearable

9,134

improving · +414 vs previous 14 d

Adherence

Companion

47.3 %

stable · +1.3 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 41 from the failing basin, 49 from restoration.

Would help

NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 61%
SC-12 Supportive Compound
76% improved among 51 similar · onset 6 d · confidence 61%
CR-01 Clinician Review
100% improved among 8 similar · onset 5 d · confidence 61%

Would not help

Keep fat low
GI +4.3 next day on high-intake days · n 18

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+4.3detractor · 95%
Insoluble fibre
+0.9no signal · 15%
Alcohol
+0.9no signal · 26%
Spicy / capsaicin
-0.9no signal · 22%
Histamine load
-0.7no signal · 21%
Simple carbohydrates
+0.7no signal · 17%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 26/100
- MicrobiomeF. prausnitzii depleted
Autonomic recovery ↑45
- WearableResting HR 78 bpm
- WearableShort sleep window
Mucosal barrier integrity ↓40
- MicrobiomeAkkermansia low → thinner mucus layer
- WearableSleep 6.0 h, below personal baseline
Inflammatory signalling ↓40
- BloodInflammatory load index 44
- WearableHRV 25 ms, trending down
Drug metabolism and exposure ↑20
- BloodToxicity index 44

DNA

Fictional pharmacogenomic panel

CYP2D6 Rapid metabolizer
Expected exposure

Microbiome

Shannon diversity 3 · butyrate capacity 26/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 22 ms
Sleep: 6.5 h
Steps: 8,654
Resting HR: 77 bpm

Daily log: GI score 38, nutritional resilience 52, adherence 47.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01431	60%	S14	GI-04	improved	41
P-01323	55%	S14	GI-04	improved	50
P-01330	54%	S14	GI-04	improved	47
P-01556	52%	S14	GI-04	improved	44
P-01688	52%	S01	GI-04	improved	40
P-01365	50%	S14	SC-12	improved	49
P-01573	50%	S14	GI-04	improved	49
P-01649	50%	S14	GI-04	improved	46
P-01501	49%	S14	GI-04	improved	45
P-01709	49%	S14	GI-04	improved	43
P-01879	49%	S14	SC-12	improved	51
P-01429	48%	S09	GI-04	improved	45