Patient P-01539
Therapy response
Declining
Tolerance
Improving
GI state
Unstable
Inflammatory state
Stable
Nutritional resilience
Stable
Discontinuation risk
84%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 43 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 55 GI-04 recommended — GI Support Protocol GI-04
- Day 56 Patient accepted — Started GI-04 in the companion
- Day 61 ME-01 recommended — Monitoring Escalation ME-01
- Day 62 Patient accepted — Started ME-01 in the companion
- Day 64 GI symptom burden −26% vs expected — GI Support Protocol GI-04
- Day 65 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
- Day 70 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 43.
Primary contributors, last 14 days
- Treatment adherence-11
- GI instability+10
- Toxicity-5
What helped?
- GI Support Protocol GI-04Day 55Result: symptom burden −26%
- Monitoring Escalation ME-01Day 61Result: deterioration detected before clinical escalation
LIFE OS recommendation
Dietary Support Protocol NP-02
57%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 66% showed improvement
- median effect visible after 10 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion60.3/100
worsening · +3.4 vs previous 14 d
Toxicity
Blood48.4/100
worsening · +7.1 vs previous 14 d
Sleep quality
Wearable37.6/100
worsening · -6.8 vs previous 14 d
Energy level
Daily log3.4/10
worsening · -0.8 vs previous 14 d
Stress level
Daily log6.6/10
worsening · +0.5 vs previous 14 d
Steps
Wearable2,957
worsening · -505 vs previous 14 d
Adherence
Companion50.9 %
worsening · -17.9 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 24 from the failing basin, 65 from restoration.
Would help
Would not help
- Keep histamine lowGI +4.3 next day on high-intake days · n 27
- Keep fat lowGI +3.8 next day on high-intake days · n 27
- Keep simple carbs lowGI +3.2 next day on high-intake days · n 21
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+4.3detractor · 95%
- Dietary fat load+3.8detractor · 95%
- Simple carbohydrates+3.2detractor · 94%
- Spicy / capsaicin+1.7no signal · 44%
- Insoluble fibre-0.5no signal · 15%
- Alcohol+0.2no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 60 and rising
- Inflammatory signalling ↓70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 56
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 28/100
- Daily logFibre intake low in recent food logs
- Drug metabolism and exposure ↑20
- BloodToxicity index 48
- Autonomic recovery ↑20
- Wearable2,957 steps/day
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.8 · butyrate capacity 28/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 44 ms
- Sleep
- 7.0 h
- Steps
- 2,514
- Resting HR
- 70 bpm
Daily log: GI score 60, nutritional resilience 44, adherence 51.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01386 | 22% | S13 | — | — | 70 |
| P-01352 | 22% | S20 | — | — | 70 |
| P-01750 | 23% | S16 | — | — | 69 |
| P-01699 | 28% | S04 | GI-04 | improved | 69 |
| P-01508 | 23% | S18 | — | — | 68 |
| P-01509 | 24% | S17 | — | — | 68 |
| P-01877 | 27% | S01 | CR-01 | improved | 67 |
| P-01515 | 22% | S16 | — | — | 66 |
| P-01629 | 23% | S19 | — | — | 66 |
| P-01714 | 28% | S14 | GI-04 | improved | 66 |
| P-01858 | 32% | S14 | NP-02 | improved | 65 |
| P-01317 | 24% | S19 | — | — | 65 |