Patient P-01559

Synthetic patientNBL-101 · Day 119 · 45–54 · F · baseline S06Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Stable

GI state

Stable

Inflammatory state

Deteriorating

Nutritional resilience

Stable

Discontinuation risk

54%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S06
Day 47 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 60 GI-04 recommended — GI Support Protocol GI-04
Day 61 Patient accepted — Started GI-04 in the companion
Day 67 ME-01 recommended — Monitoring Escalation ME-01
Day 68 Patient accepted — Started ME-01 in the companion
Day 69 GI symptom burden −29% vs expected — GI Support Protocol GI-04
Day 71 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
Day 75 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 47.

Primary contributors, last 14 days

Inflammatory activity+10
Treatment adherence+5
GI instability+4
Nutritional resilience+3
Toxicity-2

What helped?

GI Support Protocol GI-04Day 60
Result: symptom burden −29%
Monitoring Escalation ME-01Day 67
Result: deterioration detected before clinical escalation

LIFE OS recommendation

Dietary Support Protocol NP-02

55%

probability of meaningful tolerance improvement

284 similar trajectories
66% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

44.4/100

improving · -10.0 vs previous 14 d

Toxicity

Blood

40.3/100

stable · -0.2 vs previous 14 d

Sleep quality

Wearable

33.2/100

improving · +4.3 vs previous 14 d

Energy level

Daily log

3.9/10

improving · +0.3 vs previous 14 d

Stress level

Daily log

5.7/10

improving · -0.3 vs previous 14 d

Steps

Wearable

7,728

improving · +769 vs previous 14 d

Adherence

Companion

50.9 %

improving · +2.2 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 35 from the failing basin, 52 from restoration.

Would help

NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 66%
SC-12 Supportive Compound
76% improved among 51 similar · onset 6 d · confidence 66%
CR-01 Clinician Review
100% improved among 7 similar · onset 5 d · confidence 66%

Would not help

Keep fat low
GI +4.4 next day on high-intake days · n 17
Keep histamine low
GI +4 next day on high-intake days · n 20
Keep alcohol low
GI +3.7 next day on high-intake days · n 21

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+4.4detractor · 95%
Histamine load
+4detractor · 95%
Alcohol
+3.7detractor · 95%
Simple carbohydrates
+3detractor · 95%
Insoluble fibre
-0.5no signal · 15%
Spicy / capsaicin
+0.3no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 23/100
- MicrobiomeF. prausnitzii depleted
Autonomic recovery ↓45
- WearableResting HR 78 bpm
- WearableShort sleep window
Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation
Inflammatory signalling ↑25
- BloodInflammatory load index 49
Drug metabolism and exposure ↑20
- BloodToxicity index 40

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Normal metabolizer
Expected exposure

Microbiome

Shannon diversity 2.9 · butyrate capacity 23/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 59 ms
Sleep: 6.5 h
Steps: 8,420
Resting HR: 76 bpm

Daily log: GI score 44, nutritional resilience 50, adherence 51.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01486	53%	S18	GI-04	improved	47
P-01505	53%	S14	NP-02	improved	41
P-01356	52%	S14	GI-04	improved	42
P-01413	52%	S14	GI-04	improved	44
P-01566	52%	S09	GI-04	improved	52
P-01389	51%	S14	SC-12	improved	46
P-01603	51%	S14	GI-04	improved	40
P-01713	51%	S04	GI-04	improved	46
P-01365	50%	S14	SC-12	improved	49
P-01458	50%	S14	GI-04	improved	44
P-01394	49%	S05	SC-12	improved	44
P-01746	49%	S14	NP-02	improved	47