Patient P-01356
Therapy response
Unstable
Tolerance
Improving
GI state
Stable
Inflammatory state
Stable
Nutritional resilience
Unstable
Discontinuation risk
66%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 49 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 52 SC-12 recommended — Supportive Compound SC-12
- Day 53 Patient accepted — Started SC-12 in the companion
- Day 59 No meaningful change — Supportive Compound SC-12
- Day 60 GI-04 recommended — GI Support Protocol GI-04
- Day 61 Patient accepted — Started GI-04 in the companion
- Day 69 GI symptom burden −21% vs expected — GI Support Protocol GI-04
- Day 75 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 49.
Primary contributors, last 14 days
- Toxicity-11
- Nutritional resilience-7
- GI instability+4
- Treatment adherence-4
What helped?
- Supportive Compound SC-12Day 52Result: no meaningful change
- GI Support Protocol GI-04Day 60Result: symptom burden −21%
LIFE OS recommendation
Dietary Support Protocol NP-02
59%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 66% showed improvement
- median effect visible after 10 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓60
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 48 and rising
- WearableSleep 5.7 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 24/100
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 47
- Autonomic recovery ↓40
- Wearable2,806 steps/day
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 3 · butyrate capacity 24/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 55 ms
- Sleep
- 5.9 h
- Steps
- 2,783
- Resting HR
- 70 bpm
Daily log: GI score 48, nutritional resilience 39, adherence 48.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01389 | 60% | S14 | SC-12 | improved | 46 |
| P-01505 | 56% | S14 | NP-02 | improved | 41 |
| P-01458 | 55% | S14 | GI-04 | improved | 44 |
| P-01365 | 53% | S14 | SC-12 | improved | 49 |
| P-01413 | 53% | S14 | GI-04 | improved | 44 |
| P-01781 | 53% | S14 | NP-02 | improved | 45 |
| P-01436 | 52% | S14 | GI-04 | improved | 38 |
| P-01559 | 52% | S06 | GI-04 | improved | 42 |
| P-01307 | 51% | S14 | GI-04 | improved | 43 |
| P-01556 | 50% | S14 | GI-04 | improved | 44 |
| P-01616 | 50% | S14 | GI-04 | improved | 39 |
| P-01486 | 49% | S18 | GI-04 | improved | 47 |