Patient P-01611
Synthetic patientNBL-101 · Day 109 · 35–44 · F · baseline S14Steering view · 3DOpen companion preview
Therapy response
Stable
Tolerance
Deteriorating
GI state
Stable
Inflammatory state
Stable
Nutritional resilience
Stable
Discontinuation risk
65%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 31 NP-02 recommended — Dietary Support Protocol NP-02
- Day 32 Patient accepted — Started NP-02 in the companion
- Day 42 No meaningful change — Dietary Support Protocol NP-02
- Day 47 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 50 GI-04 recommended — GI Support Protocol GI-04
- Day 51 Patient accepted — Started GI-04 in the companion
- Day 59 GI symptom burden −34% vs expected — GI Support Protocol GI-04
- Day 65 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 47.
Primary contributors, last 14 days
- Toxicity+6
- Inflammatory activity+3
- Nutritional resilience+2
What helped?
- Dietary Support Protocol NP-02Day 31Result: no meaningful change
- GI Support Protocol GI-04Day 50Result: symptom burden −34%
LIFE OS recommendation
Monitoring Escalation ME-01
81%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 100% showed improvement
- median effect visible after 3 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion53.3/100
worsening · +10.4 vs previous 14 d
Toxicity
Blood40.8/100
stable · +0.6 vs previous 14 d
Sleep quality
Wearable30.4/100
worsening · -4.0 vs previous 14 d
Energy level
Daily log3.4/10
worsening · -0.8 vs previous 14 d
Stress level
Daily log7.1/10
worsening · +0.7 vs previous 14 d
Steps
Wearable2,194
stable · -22 vs previous 14 d
Adherence
Companion49.2 %
worsening · -3.9 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 29 from the failing basin, 59 from restoration.
Would help
Would not help
- NP-02 Dietary Support Protocolalready tried, no meaningful change
- Keep histamine lowGI +3.8 next day on high-intake days · n 13
- Keep fat lowGI +3.5 next day on high-intake days · n 22
- Keep spicy lowGI +2.5 next day on high-intake days · n 19
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+3.8detractor · 95%
- Dietary fat load+3.5detractor · 95%
- Spicy / capsaicin+2.5detractor · 89%
- Simple carbohydrates+2.4detractor · 86%
- Insoluble fibre+1.4no signal · 45%
- Alcohol-0.3no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 53 and rising
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 22/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 54
- WearableHRV 33 ms, trending down
- Autonomic recovery ↑40
- Wearable2,194 steps/day
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 41
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.6 · butyrate capacity 22/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 31 ms
- Sleep
- 5.4 h
- Steps
- 1,886
- Resting HR
- 75 bpm
Daily log: GI score 53, nutritional resilience 48, adherence 49.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01556 | 60% | S14 | GI-04 | improved | 44 |
| P-01570 | 57% | S14 | SC-12 | improved | 46 |
| P-01431 | 54% | S14 | GI-04 | improved | 41 |
| P-01349 | 53% | S14 | GI-04 | improved | 38 |
| P-01705 | 53% | S14 | GI-04 | improved | 39 |
| P-01603 | 52% | S14 | GI-04 | improved | 40 |
| P-01667 | 52% | S10 | GI-04 | improved | 49 |
| P-01649 | 51% | S14 | GI-04 | improved | 46 |
| P-01458 | 50% | S14 | GI-04 | improved | 44 |
| P-01543 | 50% | S14 | GI-04 | improved | 54 |
| P-01614 | 50% | S14 | GI-04 | improved | 53 |
| P-01688 | 50% | S01 | GI-04 | improved | 40 |