DeepGene damage signature
SyntheticSynthetic demo data2 samples: baseline day 0 · retest day 90
Damage score · retest day 90
46/100
vs baseline (day 0)
-19
6 improved · 2 worsened
synthetic signature · consistent with this patient's biology
- 1 opportunist above range: Clostridioides difficile
- 3 keystone species absent
- Shannon 2.56 (expected ≥ 3)
- 8 resistance genes
- Tissue recycling index 42
Pathogens / opportunists1/5
↓ from 3
Keystone species3/8
↓ from 4
Diversity1/2
Metabolic modules0/4
Vitamin synthesis3/7
Oral translocation1/1
Host DNA0/1
Tissue recycling1/1
Central mechanisms0/2
↓ from 2
Virulence factors3/3
↓ from 4
Antibiotic resistance genes8/8
↑ from 6
Genetic predisposition2/2
Opportunists above range
Clostridioides difficile 1.813% AR
Keystone species absent
Akkermansia muciniphila, Bifidobacterium longum, Butyricicoccus pullicaecorum
Capacity
Shannon 2.56 · butyrate 619 CPM · SCFA 970
3 vitamins below
Host & mechanisms
tissue recycling 42/100
oral translocation 4.13% AR
8 resistance genes · 3 virulence factors
Import a sample
A baseline sample re-initializes this patient's microbiome, pathways and predispositions from the measurement; a retest adds a comparison and updates them. Every theory, steering gain and dietary sensitivity downstream is then conditioned on the measured signature.
All elements · baseline → latest
Value, status vs the expected range, and the implication on health. Changes coloured: green improved / resolved, red worsened / new.
Pathogens / opportunists · 5
| Escherichia coli | 20.555 % AR · above range | 0.343 % AR · in range(improved) | expected <= 1% | In excess raises LPS load and zonulin release, opening tight junctions. |
| Klebsiella pneumoniae | 6.167 % AR · above range | 0.04 % AR · in range(improved) | expected <= 0.3% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Enterococcus faecium | 0.218 % AR · in range | 0.281 % AR · in range | expected <= 0.5% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Streptococcus gallolyticus | 0.049 % AR · in range | 0.028 % AR · in range | expected <= 0.1% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Clostridioides difficile | 2.056 % AR · above range | 1.813 % AR · above range | expected <= 0.1% | Opportunist above range; relevant after antibiotics and in inflammation. |
Keystone species · 8
| Akkermansia muciniphila | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Bifidobacterium longum | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Butyricicoccus pullicaecorum | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Eubacterium rectale | 0 % AR · absent | 0.74 % AR · in range(improved) | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Faecalibacterium prausnitzii | 0.23 % AR · in range | 0.59 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Lactobacillus species | 0.82 % AR · in range | 1.43 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Roseburia intestinalis | 0.64 % AR · in range | 1.14 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Ruminococcus bromii | 0.93 % AR · in range | 1.24 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
Diversity · 2
| indice Shannon | 2.67 · below range | 2.56 · below range | expected >= 3.0 | Low diversity: fewer reserve metabolic routes, slower recovery after perturbation. |
| numar de specii detectate | 101 specii · in range | 100 specii · in range | expected >= 100 | Species count below reference. |
Metabolic modules · 4
| Butyrate production | 536 CPM · in range | 619 CPM · in range | expected 255.83-1089.91 CPM | Butyrate is the main colonocyte fuel and barrier signal. |
| Short Chain Fatty Acid Production | 957 CPM · in range | 970 CPM · in range | expected 535.03-1572.59 CPM | Total SCFA capacity. |
| GABA production | 310 CPM · in range | 312 CPM · in range | expected 87.31-766.53 CPM | Gut–brain axis capacity. |
| H2S production (sulfate reduction) | 96 CPM · in range | 129 CPM · in range | expected banda de referinta | Hydrogen sulfide above band irritates the mucosa. |
Vitamin synthesis · 7
| Vitamin B1 - Thiamin | 429 CPM · below range | 345 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B2 - Riboflavin | 503 CPM · below range | 385 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B5 - Pantothenic acid | 358 CPM · below range | 294 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B6 - Pyridoxine | 4410 CPM · in range | 4357 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B7 - Biotin | 3409 CPM · in range | 2880 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B9 - Folate | 3737 CPM · in range | 3189 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B12 - Cobalamin | 3823 CPM · in range | 3386 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
Oral translocation · 1
| Translocare orala (indice) | 4.67 % AR · above range | 4.13 % AR · above range | expected <= 2% | Oral taxa in stool: reduced gastric barrier or dysbiosis. |
Host DNA · 1
| fragmentare mixta | 158 pb · in range | 159 pb · in range | expected 150-170 pb | Host cell-free DNA fragmentation pattern. |
Tissue recycling · 1
| indice de reciclare tisulara | 43 /100 · above range | 42 /100 · above range | expected < 35 | Epithelial turnover. |
Central mechanisms · 2
| molecular_mimicry | 69 /100 · above range | 61 /100 · in range(improved) | expected < 65 | Cross-reactive antigen load. |
| estrobolome | 66 /100 · above range | 60 /100 · in range(improved) | expected < 65 | Estrogen-recycling capacity. |
Virulence factors · 4
| fimD outer membrane usher | 22 potriviri/M · present | 24 potriviri/M · present | expected absent | Virulence factor detected. |
| chuA heme/hemoglobin receptor | 68 potriviri/M · present | 37 potriviri/M · present | expected absent | Virulence factor detected. |
| irp2 yersiniabactin synthetase | 59 potriviri/M · present | 40 potriviri/M · present | expected absent | Virulence factor detected. |
| espX4 type III secretion | 72 potriviri/M · present | resolved(resolved) | expected absent | Virulence factor detected. |
Antibiotic resistance genes · 8
| sul1 | 4.2 citiri/M · present | 3.3 citiri/M · present | expected nedetectat | Resistance gene detected. |
| sul2 | 7.6 citiri/M · present | 2.4 citiri/M · present | expected nedetectat | Resistance gene detected. |
| tet(O/M/O) | 1.8 citiri/M · present | 1.2 citiri/M · present | expected nedetectat | Resistance gene detected. |
| Ecol_ampC_BLA | 5.3 citiri/M · present | 7.4 citiri/M · present | expected nedetectat | Resistance gene detected. |
| aadA | 4.2 citiri/M · present | 2.3 citiri/M · present | expected nedetectat | Resistance gene detected. |
| dfrA1 | 8.5 citiri/M · present | 5.6 citiri/M · present | expected nedetectat | Resistance gene detected. |
| APH(6)-Id | — | 4.7 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
| Erm(49) | — | 5.2 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
Genetic predisposition · 2
| FUT2 | 3.44 OR · risk variant | 3.34 OR · risk variant | expected reference genotype | Reduced mucosal fucosylation |
| CYP2D6 | 3.14 OR · risk variant | 3.32 OR · risk variant | expected reference genotype | Expected exposure |