Patient P-01705

Synthetic patientNBL-101 · Day 104 · 65–74 · M · baseline S14Steering view · 3D Open companion preview

Therapy response

Unstable

Tolerance

Stable

GI state

Deteriorating

Inflammatory state

Deteriorating

Nutritional resilience

Unstable

Discontinuation risk

93%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 47 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 49 SC-12 recommended — Supportive Compound SC-12
Day 50 GI-04 recommended — GI Support Protocol GI-04
Day 50 Patient declined — Not now
Day 51 Patient accepted — Started GI-04 in the companion
Day 59 GI symptom burden −39% vs expected — GI Support Protocol GI-04
Day 65 Tolerance state changed — Unstable → Improving
Day 69 ME-01 recommended — Monitoring Escalation ME-01
Day 70 Patient accepted — Started ME-01 in the companion
Day 73 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 47.

Primary contributors, last 14 days

GI instability+22
Nutritional resilience-16
Inflammatory activity+14
Treatment adherence-3
Toxicity+3

What helped?

Supportive Compound SC-12Day 49
Declined by patient
GI Support Protocol GI-04Day 50
Result: symptom burden −39%
Monitoring Escalation ME-01Day 69
Result: deterioration detected before clinical escalation

LIFE OS recommendation

Dietary Support Protocol NP-02

61%

probability of meaningful tolerance improvement

284 similar trajectories
66% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

54.1/100

worsening · +5.8 vs previous 14 d

Toxicity

Blood

42.8/100

improving · -4.4 vs previous 14 d

Sleep quality

Wearable

27/100

worsening · -5.2 vs previous 14 d

Energy level

Daily log

3.6/10

worsening · -0.3 vs previous 14 d

Stress level

Daily log

6.9/10

stable · +0.1 vs previous 14 d

Steps

Wearable

6,998

stable · -21 vs previous 14 d

Adherence

Companion

48 %

improving · +5.3 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 25 from the failing basin, 62 from restoration.

Would help

NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 74%
SC-12 Supportive Compound
76% improved among 51 similar · onset 6 d · confidence 74%
CR-01 Clinician Review
100% improved among 8 similar · onset 5 d · confidence 74%

Would not help

Keep fat low
GI +7.5 next day on high-intake days · n 23
Keep spicy low
GI +6.9 next day on high-intake days · n 20

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+7.5detractor · 95%
Spicy / capsaicin
+6.9detractor · 95%
Histamine load
-2.2no signal · 34%
Alcohol
+0.5no signal · 15%
Insoluble fibre
-0.4no signal · 15%
Simple carbohydrates
+0.1no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 54
- WearableHRV 20 ms, trending down
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 25/100
- Daily logFibre intake low in recent food logs
Mucosal barrier integrity ↓50
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 54 and rising
Autonomic recovery ↓25
- WearableResting HR 81 bpm
Drug metabolism and exposure ↑20
- BloodToxicity index 43

DNA

Fictional pharmacogenomic panel

IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Rapid metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 3 · butyrate capacity 25/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 24 ms
Sleep: 6.8 h
Steps: 7,406
Resting HR: 80 bpm

Daily log: GI score 54, nutritional resilience 39, adherence 48.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01349	53%	S14	GI-04	improved	38
P-01611	53%	S14	GI-04	improved	44
P-01431	48%	S14	GI-04	improved	41
P-01688	47%	S01	GI-04	improved	40
P-01496	46%	S14	SC-12	improved	46
P-01570	46%	S14	SC-12	improved	46
P-01663	46%	S14	GI-04	improved	48
P-01330	45%	S14	GI-04	improved	47
P-01332	45%	S14	NP-02	improved	43
P-01341	45%	S14	GI-04	improved	47
P-01667	45%	S10	GI-04	improved	49
P-01336	44%	S03	GI-04	improved	51