Patient P-01716
Synthetic patientNBL-101 · Day 114 · 45–54 · M · baseline S14Steering view · 3DOpen companion preview
Therapy response
Improving
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Unstable
Discontinuation risk
81%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 50 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 54 GI-04 recommended — GI Support Protocol GI-04
- Day 55 Patient accepted — Started GI-04 in the companion
- Day 63 GI symptom burden −19% vs expected — GI Support Protocol GI-04
- Day 69 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 50.
Primary contributors, last 14 days
- Nutritional resilience-9
- GI instability+7
- Inflammatory activity+7
- Toxicity+7
- Treatment adherence-4
What helped?
- GI Support Protocol GI-04Day 54Result: symptom burden −19%
LIFE OS recommendation
Dietary Support Protocol NP-02
65%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 66% showed improvement
- median effect visible after 10 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion55.6/100
worsening · +8.7 vs previous 14 d
Toxicity
Blood53.2/100
stable · +0.0 vs previous 14 d
Sleep quality
Wearable23.8/100
worsening · -4.4 vs previous 14 d
Energy level
Daily log2.7/10
worsening · -0.2 vs previous 14 d
Stress level
Daily log6.5/10
worsening · +0.4 vs previous 14 d
Steps
Wearable6,555
worsening · -940 vs previous 14 d
Adherence
Companion43.6 %
stable · -1.9 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 36 from the failing basin, 56 from restoration.
Would help
Would not help
- Keep fat lowGI +6.8 next day on high-intake days · n 20
- Keep histamine lowGI +6 next day on high-intake days · n 20
- Keep simple carbs lowGI +5.1 next day on high-intake days · n 14
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+6.8detractor · 95%
- Histamine load+6detractor · 95%
- Simple carbohydrates+5.1detractor · 95%
- Insoluble fibre+3.9detractor · 87%
- Spicy / capsaicin-0.3no signal · 15%
- Alcohol+0.2no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 56 and rising
- WearableSleep 6.0 h, below personal baseline
- Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 53
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 41/100
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 56
- Autonomic recovery ↑20
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 2.6 · butyrate capacity 41/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 44 ms
- Sleep
- 6.1 h
- Steps
- 7,146
- Resting HR
- 68 bpm
Daily log: GI score 56, nutritional resilience 39, adherence 44.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.