DeepGene damage signature
SyntheticSynthetic demo data2 samples: baseline day 0 · retest day 90
Damage score · retest day 90
89/100
vs baseline (day 0)
+39
0 improved · 21 worsened
synthetic signature · consistent with this patient's biology
- 5 opportunists above range: Escherichia coli, Klebsiella pneumoniae, Enterococcus faecium
- 6 keystone species absent
- Shannon 1.92 (expected ≥ 3)
- 11 resistance genes
- Host DNA fragmentation atypical
- Tissue recycling index 64
Pathogens / opportunists5/5
↑ from 0
Keystone species6/8
↑ from 3
Diversity2/2
↑ from 1
Metabolic modules1/4
↑ from 0
Vitamin synthesis5/7
↑ from 3
Oral translocation1/1
Host DNA1/1
Tissue recycling1/1
Central mechanisms2/2
↑ from 0
Species dominance1/1
↑ from 0
Virulence factors6/6
↑ from 3
Antibiotic resistance genes11/11
↑ from 8
Genetic predisposition2/2
Opportunists above range
Escherichia coli 32.033% AR
Enterococcus faecium 16.017% AR
Klebsiella pneumoniae 9.61% AR
Streptococcus gallolyticus 3.203% AR
Keystone species absent
Akkermansia muciniphila, Bifidobacterium longum, Butyricicoccus pullicaecorum, Eubacterium rectale, Faecalibacterium prausnitzii
Capacity
Shannon 1.92 · butyrate 288 CPM · SCFA 641
H2S above band
5 vitamins below
Host & mechanisms
host DNA fragmentation atypical
tissue recycling 64/100
oral translocation 7.26% AR
molecular_mimicry above
estrobolome above
11 resistance genes · 6 virulence factors
Import a sample
A baseline sample re-initializes this patient's microbiome, pathways and predispositions from the measurement; a retest adds a comparison and updates them. Every theory, steering gain and dietary sensitivity downstream is then conditioned on the measured signature.
All elements · baseline → latest
Value, status vs the expected range, and the implication on health. Changes coloured: green improved / resolved, red worsened / new.
Pathogens / opportunists · 5
| Escherichia coli | 0.19 % AR · in range | 32.033 % AR · above range(worsened) | expected <= 1% | In excess raises LPS load and zonulin release, opening tight junctions. |
| Klebsiella pneumoniae | 0.21 % AR · in range | 9.61 % AR · above range(worsened) | expected <= 0.3% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Enterococcus faecium | 0.347 % AR · in range | 16.017 % AR · above range(worsened) | expected <= 0.5% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Streptococcus gallolyticus | 0.07 % AR · in range | 3.203 % AR · above range(worsened) | expected <= 0.1% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Clostridioides difficile | 0.043 % AR · in range | 3.203 % AR · above range(worsened) | expected <= 0.1% | Opportunist above range; relevant after antibiotics and in inflammation. |
Keystone species · 8
| Akkermansia muciniphila | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Bifidobacterium longum | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Butyricicoccus pullicaecorum | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Eubacterium rectale | 1.06 % AR · in range | 0 % AR · absent(worsened) | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Faecalibacterium prausnitzii | 1.15 % AR · in range | 0 % AR · absent(worsened) | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Lactobacillus species | 0.59 % AR · in range | 0 % AR · absent(worsened) | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Roseburia intestinalis | 0.28 % AR · in range | 1.43 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Ruminococcus bromii | 1.15 % AR · in range | 1.38 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
Diversity · 2
| indice Shannon | 2.54 · below range | 1.92 · below range | expected >= 3.0 | Low diversity: fewer reserve metabolic routes, slower recovery after perturbation. |
| numar de specii detectate | 109 specii · in range | 52 specii · below range(worsened) | expected >= 100 | Species count below reference. |
Metabolic modules · 4
| Butyrate production | 564 CPM · in range | 288 CPM · in range | expected 255.83-1089.91 CPM | Butyrate is the main colonocyte fuel and barrier signal. |
| Short Chain Fatty Acid Production | 919 CPM · in range | 641 CPM · in range | expected 535.03-1572.59 CPM | Total SCFA capacity. |
| GABA production | 298 CPM · in range | 164 CPM · in range | expected 87.31-766.53 CPM | Gut–brain axis capacity. |
| H2S production (sulfate reduction) | 137 CPM · in range | 391 CPM · above range(worsened) | expected banda de referinta | Hydrogen sulfide above band irritates the mucosa. |
Vitamin synthesis · 7
| Vitamin B1 - Thiamin | 429 CPM · below range | 279 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B2 - Riboflavin | 545 CPM · below range | 231 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B5 - Pantothenic acid | 169 CPM · below range | 483 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B6 - Pyridoxine | 2799 CPM · in range | 262 CPM · below range(worsened) | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B7 - Biotin | 3713 CPM · in range | 328 CPM · below range(worsened) | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B9 - Folate | 3464 CPM · in range | 2760 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B12 - Cobalamin | 3637 CPM · in range | 3753 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
Oral translocation · 1
| Translocare orala (indice) | 4.43 % AR · above range | 7.26 % AR · above range | expected <= 2% | Oral taxa in stool: reduced gastric barrier or dysbiosis. |
Host DNA · 1
| fragmentare mixta | 247 pb · atypical | 250 pb · atypical | expected 150-170 pb | Host cell-free DNA fragmentation pattern. |
Tissue recycling · 1
| indice de reciclare tisulara | 42 /100 · above range | 64 /100 · above range | expected < 35 | Epithelial turnover. |
Central mechanisms · 2
| molecular_mimicry | 62 /100 · in range | 77 /100 · above range(worsened) | expected < 65 | Cross-reactive antigen load. |
| estrobolome | 65 /100 · in range | 76 /100 · above range(worsened) | expected < 65 | Estrogen-recycling capacity. |
Species dominance · 1
| Bifidobacterium breve | — | 23.01 % AR · above range(new) | expected < 20% per specie | One species occupies the niche of others. |
Virulence factors · 6
| fimD outer membrane usher | 91 potriviri/M · present | 26 potriviri/M · present | expected absent | Virulence factor detected. |
| chuA heme/hemoglobin receptor | 63 potriviri/M · present | 30 potriviri/M · present | expected absent | Virulence factor detected. |
| irp2 yersiniabactin synthetase | 90 potriviri/M · present | 89 potriviri/M · present | expected absent | Virulence factor detected. |
| espX4 type III secretion | — | 68 potriviri/M · present(new) | expected absent | Virulence factor detected. |
| kpsD polysialic acid transport | — | 88 potriviri/M · present(new) | expected absent | Virulence factor detected. |
| acrB acriflavine resistance | — | 21 potriviri/M · present(new) | expected absent | Virulence factor detected. |
Antibiotic resistance genes · 11
| sul1 | 9.3 citiri/M · present | 7.7 citiri/M · present | expected nedetectat | Resistance gene detected. |
| sul2 | 6.7 citiri/M · present | 5.5 citiri/M · present | expected nedetectat | Resistance gene detected. |
| tet(O/M/O) | 4.9 citiri/M · present | 10 citiri/M · present | expected nedetectat | Resistance gene detected. |
| Ecol_ampC_BLA | 6.5 citiri/M · present | 2.1 citiri/M · present | expected nedetectat | Resistance gene detected. |
| aadA | 2.6 citiri/M · present | 2.9 citiri/M · present | expected nedetectat | Resistance gene detected. |
| dfrA1 | 2.5 citiri/M · present | 9.9 citiri/M · present | expected nedetectat | Resistance gene detected. |
| APH(6)-Id | 2.5 citiri/M · present | 6.7 citiri/M · present | expected nedetectat | Resistance gene detected. |
| Erm(49) | 7.2 citiri/M · present | 8.8 citiri/M · present | expected nedetectat | Resistance gene detected. |
| msrC | — | 7.5 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
| eptB | — | 9.4 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
| ugd | — | 1 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
Genetic predisposition · 2
| FUT2 | 2.21 OR · risk variant | 3.09 OR · risk variant | expected reference genotype | Reduced mucosal fucosylation |
| CYP2D6 | 2.32 OR · risk variant | 2.33 OR · risk variant | expected reference genotype | Expected exposure |