Patient P-01786
Synthetic patientNBL-101 · Day 94 · 65–74 · F · baseline S07Steering view · 3DOpen companion preview
Therapy response
Declining
Tolerance
Improving
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
81%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S07
- Day 48 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 57 ME-01 recommended — Monitoring Escalation ME-01
- Day 58 Patient accepted — Started ME-01 in the companion
- Day 61 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
What changed?
Trajectory began diverging from predicted response on Day 48.
Primary contributors, last 14 days
- Toxicity-11
- GI instability-8
- Treatment adherence-8
- Inflammatory activity-7
- Nutritional resilience+5
What helped?
- Monitoring Escalation ME-01Day 57Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
87%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion58.9/100
improving · -7.4 vs previous 14 d
Toxicity
Blood47.1/100
worsening · +5.9 vs previous 14 d
Sleep quality
Wearable40.7/100
improving · +1.8 vs previous 14 d
Energy level
Daily log2.5/10
improving · +0.2 vs previous 14 d
Stress level
Daily log6.5/10
improving · -0.6 vs previous 14 d
Steps
Wearable1,052
improving · +115 vs previous 14 d
Adherence
Companion41.4 %
worsening · -14.2 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 26 from the failing basin, 63 from restoration.
Would help
Would not help
- Keep fat lowGI +5.8 next day on high-intake days · n 26
- Keep simple carbs lowGI +5.8 next day on high-intake days · n 21
- Keep fibre lowGI +4 next day on high-intake days · n 12
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+5.8detractor · 95%
- Simple carbohydrates+5.8detractor · 95%
- Insoluble fibre+4detractor · 61%
- Spicy / capsaicin+2.6no signal · 52%
- Histamine load+0.2no signal · 15%
- Alcohol+0.1no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↓65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 59
- WearableHRV 32 ms, trending down
- Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 47
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 28/100
- Daily logFibre intake low in recent food logs
- Mucosal barrier integrity ↓50
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 59 and rising
- Autonomic recovery ↑45
- WearableResting HR 80 bpm
- Wearable1,052 steps/day
DNA
Fictional pharmacogenomic panel
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.1 · butyrate capacity 28/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 32 ms
- Sleep
- 7.2 h
- Steps
- 1,170
- Resting HR
- 81 bpm
Daily log: GI score 59, nutritional resilience 41, adherence 41.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01604 | 20% | S01 | — | — | 71 |
| P-01386 | 20% | S13 | — | — | 70 |
| P-01352 | 20% | S20 | — | — | 70 |
| P-01699 | 28% | S04 | GI-04 | improved | 69 |
| P-01508 | 21% | S18 | — | — | 68 |
| P-01509 | 21% | S17 | — | — | 68 |
| P-01817 | 21% | S14 | — | — | 67 |
| P-01877 | 29% | S01 | CR-01 | improved | 67 |
| P-01629 | 22% | S19 | — | — | 66 |
| P-01714 | 25% | S14 | GI-04 | improved | 66 |
| P-01858 | 31% | S14 | NP-02 | improved | 65 |
| P-01317 | 21% | S19 | — | — | 65 |