Patient P-01805
Therapy response
Declining
Tolerance
Unstable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
62%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S10
- Day 87 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 87.
Primary contributors, last 14 days
- Toxicity+6
- GI instability-5
- Treatment adherence-5
- Inflammatory activity+3
- Nutritional resilience+3
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
62%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion63.4/100
stable · +1.3 vs previous 14 d
Toxicity
Blood61.9/100
worsening · +4.0 vs previous 14 d
Sleep quality
Wearable18.6/100
worsening · -2.6 vs previous 14 d
Energy level
Daily log2.1/10
worsening · -0.3 vs previous 14 d
Stress level
Daily log8.7/10
stable · +0.1 vs previous 14 d
Steps
Wearable3,515
worsening · -368 vs previous 14 d
Adherence
Companion67.8 %
worsening · -10.0 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 22 from the failing basin, 72 from restoration.
Would help
Would not help
- Keep fat lowGI +4.4 next day on high-intake days · n 25
- Keep alcohol lowGI +3.7 next day on high-intake days · n 21
- Keep histamine lowGI +3.6 next day on high-intake days · n 29
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+4.4detractor · 95%
- Alcohol+3.7detractor · 90%
- Histamine load+3.6detractor · 91%
- Spicy / capsaicin+2.4no signal · 54%
- Insoluble fibre-0.7no signal · 15%
- Simple carbohydrates-0.1no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 63 and rising
- WearableSleep 5.7 h, below personal baseline
- Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 68
- WearableHRV 15 ms, trending down
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 44/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑65
- WearableResting HR 76 bpm
- Wearable3,515 steps/day
- WearableShort sleep window
- Drug metabolism and exposure ↑55
- DNADPYD *2A → slower clearance
- BloodToxicity index 62
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Rapid metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 3 · butyrate capacity 44/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 16 ms
- Sleep
- 5.5 h
- Steps
- 3,240
- Resting HR
- 75 bpm
Daily log: GI score 63, nutritional resilience 34, adherence 68.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01819 | 20% | S13 | — | — | 72 |
| P-01604 | 20% | S01 | — | — | 71 |
| P-01386 | 19% | S13 | — | — | 70 |
| P-01352 | 20% | S20 | — | — | 70 |
| P-01699 | 31% | S04 | GI-04 | improved | 69 |
| P-01508 | 19% | S18 | — | — | 68 |
| P-01509 | 21% | S17 | — | — | 68 |
| P-01817 | 20% | S14 | — | — | 67 |
| P-01877 | 36% | S01 | CR-01 | improved | 67 |
| P-01629 | 21% | S19 | — | — | 66 |
| P-01714 | 22% | S14 | GI-04 | improved | 66 |
| P-01858 | 26% | S14 | NP-02 | improved | 65 |