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Patient P-01818

Synthetic patientNBL-101 · Day 109 · 65–74 · F · baseline S15Steering view · 3DOpen companion preview
Therapy response
Declining
Tolerance
Deteriorating
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Improving
Discontinuation risk
15%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 NBL-101 started — Baseline state S15
  2. Day 14 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 14.

Primary contributors, last 14 days
  • GI instability-16
  • Inflammatory activity-12
  • Nutritional resilience+10
  • Toxicity+9
  • Treatment adherence+3

What helped?

No interventions yet.

    LIFE OS recommendation
    No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

    Daily trackers

    Molecule settings

    The trackers this program marks as important, last 14 days vs the 14 before.

    GI burden
    Companion
    17.2/100
    improving · -10.0 vs previous 14 d
    Toxicity
    Blood
    25.3/100
    worsening · +2.3 vs previous 14 d
    Sleep quality
    Wearable
    52/100
    improving · +6.3 vs previous 14 d
    Energy level
    Daily log
    5.6/10
    improving · +0.5 vs previous 14 d
    Stress level
    Daily log
    4.7/10
    improving · -0.5 vs previous 14 d
    Steps
    Wearable
    6,211
    improving · +679 vs previous 14 d
    Adherence
    Companion
    91.9 %
    stable · +1.9 vs previous 14 d
    This trajectory is decaying — what would help, what would not
    Steering view →

    Heading towards restoration · 71 from the failing basin, 32 from restoration.

    Would help
    • No untried action with strong evidence. Compose one from primitives.
    Would not help
    • Keep histamine low
      GI +5.5 next day on high-intake days · n 18
    • Keep fat low
      GI +5 next day on high-intake days · n 20
    • Keep simple carbs low
      GI +3.9 next day on high-intake days · n 12
    State influencers · digestive

    Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

    • Histamine load
      +5.5detractor · 95%
    • Dietary fat load
      +5detractor · 95%
    • Simple carbohydrates
      +3.9detractor · 90%
    • Alcohol
      +2no signal · 42%
    • Insoluble fibre
      +1.7no signal · 35%
    • Spicy / capsaicin
      +1.1no signal · 21%

    Biological layers

    Which pathways look influenced, and by which layer of this person's biology.

    Pathways under pressure
    • Mucosal barrier integrity ↓60
      • DNAFUT2 non-secretor lowers mucosal fucosylation
      • MicrobiomeAkkermansia low → thinner mucus layer
    • Inflammatory signalling ↓35
      • MicrobiomeBacteroides fragilis expansion
      • WearableHRV 38 ms, trending down
    • Butyrate / short-chain fatty acid production ↓35
      • MicrobiomeButyrate capacity 38/100
    • Drug metabolism and exposure ↑35
      • DNADPYD *2A → slower clearance
    • Autonomic recovery ↓25
      • WearableResting HR 75 bpm
    DNA
    Fictional pharmacogenomic panel
    • FUT2 rs601338 AA (non-secretor)
      Reduced mucosal fucosylation
    • DPYD *2A heterozygous
      Slower drug clearance
    • CYP2D6 Normal metabolizer
      Expected exposure
    Microbiome
    Shannon diversity 2.6 · butyrate capacity 38/100
    • Akkermansia muciniphilaLow
    • Faecalibacterium prausnitziiNormal
    • Bacteroides fragilisHigh
    • Bifidobacterium longumNormal
    • EnterobacteriaceaeNormal
    Wearable, last 14 days
    daily evolution fed into the runtime
    HRV
    37 ms
    Sleep
    6.8 h
    Steps
    5,681
    Resting HR
    72 bpm
    Daily log: GI score 17, nutritional resilience 68, adherence 92.

    What this patient sees in NostraAI

    The content that steers the trajectory: what to eat, what to do, what to take.

    Open companion preview
    What to eat
    • Keep meals regular; three to four moderate portions spaced through the day
    • Include a cooked vegetable portion with each main meal
    • Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
    • Avoid known triggers for now: fried or oily food, dairy, alcohol
    What to do
    • Log the daily check-in; one line is enough
    • Keep the current walking rhythm
    • Keep the sleep window steady
    • Keep hydration steady: small amounts through the day rather than large volumes at once
    What to take
    • Take the scheduled dose as agreed with your care team
    • No additional supplements this week
    • Fictional demo item: continue vitamin D as before

    284 biologically similar trajectories

    Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

    Sort by similaritySort by interventionSort by outcomeSort by stateSort by response
    PatientSimilarityBaselineInterventionOutcomeResponse today
    P-0142025%S03——85
    P-0138428%S08——82
    P-0146027%S12——82
    P-0152525%S19——82
    P-0177026%S13——82
    P-0151225%S17——81
    P-0180327%S11——81
    P-0151025%S10——80
    P-0147726%S19——80
    P-0166426%S03——80
    P-0142227%S16——80
    P-0150325%S15ME-01improved80