Patient P-01835
Therapy response
Declining
Tolerance
Stable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
58%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S17
- Day 82 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 82 CR-01 recommended — Clinician Review CR-01
- Day 83 Patient accepted — Started CR-01 in the companion
- Day 88 Deterioration detected before clinical escalation — Clinician Review CR-01
What changed?
Trajectory began diverging from predicted response on Day 82.
Primary contributors, last 14 days
- Inflammatory activity+2
- Treatment adherence-2
- Toxicity+2
What helped?
- Clinician Review CR-01Day 82Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
63%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion61.8/100
stable · +1.0 vs previous 14 d
Toxicity
Blood55/100
worsening · +2.5 vs previous 14 d
Sleep quality
Wearable23.5/100
worsening · -3.0 vs previous 14 d
Energy level
Daily log2.5/10
stable · -0.1 vs previous 14 d
Stress level
Daily log7.6/10
stable · +0.2 vs previous 14 d
Steps
Wearable2,494
improving · +126 vs previous 14 d
Adherence
Companion70.7 %
worsening · -12.2 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 34 from the failing basin, 62 from restoration.
Would help
Would not help
- Keep histamine lowGI +4.3 next day on high-intake days · n 26
- Keep simple carbs lowGI +3.3 next day on high-intake days · n 19
- Keep fat lowGI +2.9 next day on high-intake days · n 19
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+4.3detractor · 95%
- Simple carbohydrates+3.3detractor · 95%
- Dietary fat load+2.9detractor · 83%
- Alcohol+2.7detractor · 76%
- Spicy / capsaicin+1.2no signal · 28%
- Insoluble fibre+0.5no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 24/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑60
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 60
- WearableHRV 15 ms, trending down
- Drug metabolism and exposure ↑55
- DNADPYD *2A → slower clearance
- BloodToxicity index 55
- Mucosal barrier integrity ↓50
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 62 and rising
- Autonomic recovery ↓45
- WearableResting HR 81 bpm
- Wearable2,494 steps/day
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Intermediate metabolizerExpected exposure
Microbiome
Shannon diversity 2.5 · butyrate capacity 24/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 19 ms
- Sleep
- 6.3 h
- Steps
- 2,473
- Resting HR
- 81 bpm
Daily log: GI score 62, nutritional resilience 39, adherence 71.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.