Patient P-01841
Therapy response
Stable
Tolerance
Unstable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 47 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 47.
Primary contributors, last 14 days
- Toxicity+11
- Treatment adherence+6
- Inflammatory activity+2
- Nutritional resilience+2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
92%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 84% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 32/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑65
- WearableResting HR 83 bpm
- Wearable3,196 steps/day
- WearableShort sleep window
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 71 and rising
- WearableSleep 5.4 h, below personal baseline
- Inflammatory signalling ↑25
- BloodInflammatory load index 66
- Drug metabolism and exposure ↑20
- BloodToxicity index 59
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Intermediate metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 3.1 · butyrate capacity 32/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 46 ms
- Sleep
- 5.6 h
- Steps
- 3,269
- Resting HR
- 82 bpm
Daily log: GI score 71, nutritional resilience 32, adherence 47.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01612 | 64% | S14 | ME-01 | improved | 51 |
| P-01897 | 64% | S14 | ME-01 | improved | 43 |
| P-01830 | 62% | S14 | — | — | 44 |
| P-01888 | 61% | S14 | — | — | 56 |
| P-01463 | 60% | S14 | NP-02 | no change | 41 |
| P-01572 | 60% | S14 | GI-04 | worsened | 41 |
| P-01582 | 58% | S14 | GI-04 | no change | 45 |
| P-01743 | 55% | S14 | SC-12 | no change | 52 |
| P-01762 | 55% | S14 | NP-02 | no change | 40 |
| P-01396 | 53% | S14 | GI-04 | worsened | 51 |
| P-01721 | 53% | S14 | — | — | 37 |
| P-01728 | 53% | S14 | SC-12 | improved | 41 |