Patient P-01841

Synthetic patientNBL-101 · Day 117 · 45–54 · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Unstable

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

96%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S14
Day 47 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 47.

Primary contributors, last 14 days

Toxicity+11
Treatment adherence+6
Inflammatory activity+2
Nutritional resilience+2

What helped?

No interventions yet.

LIFE OS recommendation

GI Support Protocol GI-04

92%

probability of meaningful tolerance improvement

284 similar trajectories
84% showed improvement
median effect visible after 8 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

71.3/100

improving · -8.5 vs previous 14 d

Toxicity

Blood

59.1/100

stable · +1.1 vs previous 14 d

Sleep quality

Wearable

24.3/100

improving · +2.6 vs previous 14 d

Energy level

Daily log

1.2/10

improving · +0.6 vs previous 14 d

Stress level

Daily log

6.8/10

improving · -0.4 vs previous 14 d

Steps

Wearable

3,196

improving · +662 vs previous 14 d

Adherence

Companion

47.4 %

improving · +6.5 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading drifting · 24 from the failing basin, 75 from restoration.

Would help

GI-04 GI Support Protocol
73% improved among 123 similar · onset 8 d · confidence 97%
ME-01 Monitoring Escalation
100% improved among 78 similar · onset 3 d · confidence 76%
NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 76%

Would not help

Keep histamine low
GI +4.5 next day on high-intake days · n 28
Keep alcohol low
GI +4.4 next day on high-intake days · n 24
Keep fat low
GI +3.5 next day on high-intake days · n 22

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Histamine load
+4.5detractor · 95%
Alcohol
+4.4detractor · 95%
Dietary fat load
+3.5detractor · 95%
Spicy / capsaicin
+0.7no signal · 16%
Simple carbohydrates
+0.5no signal · 15%
Insoluble fibre
-0.1no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 32/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Autonomic recovery ↑65
- WearableResting HR 83 bpm
- Wearable3,196 steps/day
- WearableShort sleep window
Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 71 and rising
- WearableSleep 5.4 h, below personal baseline
Inflammatory signalling ↑25
- BloodInflammatory load index 66
Drug metabolism and exposure ↑20
- BloodToxicity index 59

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Intermediate metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 3.1 · butyrate capacity 32/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 46 ms
Sleep: 5.6 h
Steps: 3,269
Resting HR: 82 bpm

Daily log: GI score 71, nutritional resilience 32, adherence 47.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01377	17%	S11	AD-05	no change	42
P-01689	17%	S13	BR-03	no change	50
P-01708	28%	S07	CR-01	improved	59
P-01371	23%	S06	CR-01	improved	63
P-01388	23%	S17	CR-01	improved	59
P-01696	23%	S20	CR-01	improved	59
P-01835	23%	S17	CR-01	improved	56
P-01877	23%	S01	CR-01	improved	67
P-01442	20%	S13	CR-01	improved	61
P-01430	17%	S05	CR-01	improved	54
P-01572	60%	S14	GI-04	worsened	41
P-01582	58%	S14	GI-04	no change	45