DeepGene damage signature

SyntheticSynthetic demo data2 samples: baseline day 0 · retest day 90

Damage score · retest day 90

73/100

vs baseline (day 0)

+16

2 improved · 6 worsened

synthetic signature · consistent with this patient's biology

4 opportunists above range: Escherichia coli, Klebsiella pneumoniae, Enterococcus faecium
4 keystone species absent
Shannon 2.37 (expected ≥ 3)
7 resistance genes
Host DNA fragmentation atypical
Tissue recycling index 45

Pathogens / opportunists4/5

↑ from 3

Keystone species4/8

↑ from 3

Diversity1/2

Metabolic modules0/4

Vitamin synthesis3/7

Oral translocation1/1

Host DNA1/1

↑ from 0

Tissue recycling1/1

Central mechanisms1/2

Virulence factors4/4

↑ from 3

Antibiotic resistance genes7/7

Genetic predisposition2/2

Opportunists above range

Escherichia coli 20.459% AR

Enterococcus faecium 10.229% AR

Klebsiella pneumoniae 6.138% AR

Clostridioides difficile 2.046% AR

Keystone species absent

Akkermansia muciniphila, Bifidobacterium longum, Butyricicoccus pullicaecorum, Eubacterium rectale

Capacity

Shannon 2.37 · butyrate 572 CPM · SCFA 951

3 vitamins below

Host & mechanisms

host DNA fragmentation atypical

tissue recycling 45/100

oral translocation 4.65% AR

estrobolome above

7 resistance genes · 4 virulence factors

Import a sample

day Import DeepGene CSV

A baseline sample re-initializes this patient's microbiome, pathways and predispositions from the measurement; a retest adds a comparison and updates them. Every theory, steering gain and dietary sensitivity downstream is then conditioned on the measured signature.

All elements · baseline → latest

Value, status vs the expected range, and the implication on health. Changes coloured: green improved / resolved, red worsened / new.

Pathogens / opportunists · 5

Escherichia coli	0.052 % AR · in range	20.459 % AR · above range(worsened)	expected <= 1%	In excess raises LPS load and zonulin release, opening tight junctions.
Klebsiella pneumoniae	0.07 % AR · in range	6.138 % AR · above range(worsened)	expected <= 0.3%	Opportunist above range; relevant after antibiotics and in inflammation.
Enterococcus faecium	9.091 % AR · above range	10.229 % AR · above range	expected <= 0.5%	Opportunist above range; relevant after antibiotics and in inflammation.
Streptococcus gallolyticus	1.818 % AR · above range	0.046 % AR · in range(improved)	expected <= 0.1%	Opportunist above range; relevant after antibiotics and in inflammation.
Clostridioides difficile	1.818 % AR · above range	2.046 % AR · above range	expected <= 0.1%	Opportunist above range; relevant after antibiotics and in inflammation.

Keystone species · 8

Akkermansia muciniphila	0 % AR · absent	0 % AR · absent	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Bifidobacterium longum	0 % AR · absent	0 % AR · absent	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Butyricicoccus pullicaecorum	0 % AR · absent	0 % AR · absent	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Eubacterium rectale	1.34 % AR · in range	0 % AR · absent(worsened)	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Faecalibacterium prausnitzii	0.79 % AR · in range	0.84 % AR · in range	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Lactobacillus species	0.81 % AR · in range	0.13 % AR · in range	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Roseburia intestinalis	0.11 % AR · in range	0.76 % AR · in range	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.
Ruminococcus bromii	0.06 % AR · in range	0.91 % AR · in range	expected 0.15-2.24%	Keystone butyrate producer / mucin specialist.

Diversity · 2

indice Shannon	2.76 · below range	2.37 · below range	expected >= 3.0	Low diversity: fewer reserve metabolic routes, slower recovery after perturbation.
numar de specii detectate	106 specii · in range	107 specii · in range	expected >= 100	Species count below reference.

Metabolic modules · 4

Butyrate production	574 CPM · in range	572 CPM · in range	expected 255.83-1089.91 CPM	Butyrate is the main colonocyte fuel and barrier signal.
Short Chain Fatty Acid Production	996 CPM · in range	951 CPM · in range	expected 535.03-1572.59 CPM	Total SCFA capacity.
GABA production	342 CPM · in range	280 CPM · in range	expected 87.31-766.53 CPM	Gut–brain axis capacity.
H2S production (sulfate reduction)	91 CPM · in range	138 CPM · in range	expected banda de referinta	Hydrogen sulfide above band irritates the mucosa.

Vitamin synthesis · 7

Vitamin B1 - Thiamin	273 CPM · below range	253 CPM · below range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B2 - Riboflavin	394 CPM · below range	399 CPM · below range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B5 - Pantothenic acid	161 CPM · below range	242 CPM · below range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B6 - Pyridoxine	3808 CPM · in range	4321 CPM · in range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B7 - Biotin	3337 CPM · in range	3620 CPM · in range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B9 - Folate	4045 CPM · in range	4075 CPM · in range	expected 2000-5000 CPM	Microbial synthesis capacity.
Vitamin B12 - Cobalamin	4436 CPM · in range	2817 CPM · in range	expected 2000-5000 CPM	Microbial synthesis capacity.

Oral translocation · 1

Translocare orala (indice)

4.14 % AR · above range

4.65 % AR · above range

expected <= 2%

Oral taxa in stool: reduced gastric barrier or dysbiosis.

Host DNA · 1

fragmentare mixta

157 pb · in range

239 pb · atypical(worsened)

expected 150-170 pb

Host cell-free DNA fragmentation pattern.

Tissue recycling · 1

indice de reciclare tisulara

47 /100 · above range

45 /100 · above range

expected < 35

Epithelial turnover.

Central mechanisms · 2

molecular_mimicry	68 /100 · above range	65 /100 · in range(improved)	expected < 65	Cross-reactive antigen load.
estrobolome	65 /100 · in range	67 /100 · above range(worsened)	expected < 65	Estrogen-recycling capacity.

Virulence factors · 4

fimD outer membrane usher	23 potriviri/M · present	41 potriviri/M · present	expected absent	Virulence factor detected.
chuA heme/hemoglobin receptor	83 potriviri/M · present	74 potriviri/M · present	expected absent	Virulence factor detected.
irp2 yersiniabactin synthetase	70 potriviri/M · present	21 potriviri/M · present	expected absent	Virulence factor detected.
espX4 type III secretion	—	60 potriviri/M · present(new)	expected absent	Virulence factor detected.

Antibiotic resistance genes · 7

sul1	2.4 citiri/M · present	2.4 citiri/M · present	expected nedetectat	Resistance gene detected.
sul2	1.7 citiri/M · present	5.9 citiri/M · present	expected nedetectat	Resistance gene detected.
tet(O/M/O)	3.4 citiri/M · present	9.1 citiri/M · present	expected nedetectat	Resistance gene detected.
Ecol_ampC_BLA	10.1 citiri/M · present	10 citiri/M · present	expected nedetectat	Resistance gene detected.
aadA	8.8 citiri/M · present	1.4 citiri/M · present	expected nedetectat	Resistance gene detected.
dfrA1	7.5 citiri/M · present	8.3 citiri/M · present	expected nedetectat	Resistance gene detected.
APH(6)-Id	2.4 citiri/M · present	1.5 citiri/M · present	expected nedetectat	Resistance gene detected.

Genetic predisposition · 2

DPYD	2.49 OR · risk variant	1.66 OR · risk variant	expected reference genotype	Slower drug clearance
CYP2D6	2.86 OR · risk variant	2.94 OR · risk variant	expected reference genotype	Expected exposure