Patient P-01866
Therapy response
Unstable
Tolerance
Stable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 45 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 45.
Primary contributors, last 14 days
- GI instability+8
- Inflammatory activity+7
- Treatment adherence+6
- Nutritional resilience-2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
92%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 79 and rising
- WearableSleep 5.5 h, below personal baseline
- Inflammatory signalling ↑85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 71
- WearableHRV 18 ms, trending down
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 39/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↓65
- WearableResting HR 84 bpm
- Wearable300 steps/day
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 58
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Intermediate metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.4 · butyrate capacity 39/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 21 ms
- Sleep
- 5.2 h
- Steps
- 1,149
- Resting HR
- 84 bpm
Daily log: GI score 79, nutritional resilience 30, adherence 43.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01407 | 62% | S14 | NP-02 | no change | 44 |
| P-01597 | 62% | S14 | GI-04 | no change | 43 |
| P-01619 | 56% | S14 | GI-04 | worsened | 38 |
| P-01367 | 54% | S14 | GI-04 | no change | 51 |
| P-01760 | 52% | S14 | — | — | 42 |
| P-01762 | 51% | S14 | NP-02 | no change | 40 |
| P-01582 | 48% | S14 | GI-04 | no change | 45 |
| P-01615 | 48% | S14 | ME-01 | improved | 48 |
| P-01813 | 48% | S01 | NP-02 | no change | 40 |
| P-01776 | 47% | S16 | NP-02 | no change | 47 |
| P-01854 | 47% | S14 | ME-01 | improved | 46 |
| P-01655 | 46% | S14 | GI-04 | no change | 29 |