Patient P-01887

Synthetic patientNBL-101 · Day 118 · 55–64 · F · baseline S12Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Stable

GI state

Unstable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

86%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 NBL-101 started — Baseline state S12
Day 49 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 72 ME-01 recommended — Monitoring Escalation ME-01
Day 73 Patient accepted — Started ME-01 in the companion
Day 76 Deterioration detected before clinical escalation — Monitoring Escalation ME-01

What changed?

Trajectory began diverging from predicted response on Day 49.

Primary contributors, last 14 days

Nutritional resilience-8
GI instability-2

What helped?

Monitoring Escalation ME-01Day 72
Result: deterioration detected before clinical escalation

LIFE OS recommendation

GI Support Protocol GI-04

90%

probability of meaningful tolerance improvement

284 similar trajectories
83% showed improvement
median effect visible after 8 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

GI burden

Companion

66.1/100

worsening · +8.5 vs previous 14 d

Toxicity

Blood

51.1/100

worsening · +2.9 vs previous 14 d

Sleep quality

Wearable

39.1/100

worsening · -8.5 vs previous 14 d

Energy level

Daily log

2.5/10

worsening · -0.5 vs previous 14 d

Stress level

Daily log

6.1/10

worsening · +0.7 vs previous 14 d

Steps

Wearable

6,936

worsening · -451 vs previous 14 d

Adherence

Companion

44.8 %

stable · +0.1 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading drifting · 21 from the failing basin, 71 from restoration.

Would help

GI-04 GI Support Protocol
73% improved among 124 similar · onset 8 d · confidence 94%
NP-02 Dietary Support Protocol
63% improved among 64 similar · onset 10 d · confidence 76%
SC-12 Supportive Compound
76% improved among 51 similar · onset 6 d · confidence 76%

Would not help

Keep fat low
GI +7.4 next day on high-intake days · n 23
Keep simple carbs low
GI +6.3 next day on high-intake days · n 21
Keep histamine low
GI +6.2 next day on high-intake days · n 17

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Dietary fat load
+7.4detractor · 95%
Simple carbohydrates
+6.3detractor · 95%
Histamine load
+6.2detractor · 95%
Insoluble fibre
+5.4detractor · 95%
Spicy / capsaicin
+4.3detractor · 73%
Alcohol
-1.8no signal · 29%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 66 and rising
Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 51
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 42/100
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↑50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 61
Autonomic recovery ↓45
- WearableResting HR 78 bpm
- WearableShort sleep window

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Poor metabolizer
Higher exposure at standard dose

Microbiome

Shannon diversity 2.8 · butyrate capacity 42/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 47 ms
Sleep: 6.1 h
Steps: 6,343
Resting HR: 79 bpm

Daily log: GI score 66, nutritional resilience 29, adherence 45.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
Keep the current walking rhythm
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-01386	18%	S13	—	—	70
P-01352	18%	S20	—	—	70
P-01750	19%	S16	—	—	69
P-01699	23%	S04	GI-04	improved	69
P-01508	19%	S18	—	—	68
P-01509	20%	S17	—	—	68
P-01875	19%	S11	—	—	67
P-01877	23%	S01	CR-01	improved	67
P-01515	18%	S16	—	—	66
P-01629	19%	S19	—	—	66
P-01714	22%	S14	GI-04	improved	66
P-01858	28%	S14	NP-02	improved	65