Patient P-03021
Therapy response
Stable
Tolerance
Deteriorating
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Improving
Discontinuation risk
51%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S15
- Day 100 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 100.
Primary contributors, last 14 days
- GI instability-15
- Nutritional resilience+12
- Treatment adherence-11
- Inflammatory activity-7
- Toxicity+6
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
60%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log3/10
worsening · -0.6 vs previous 14 d
Stress level
Daily log5.9/10
stable · +0.2 vs previous 14 d
Pessimism score
Daily log5.6/10
stable · +0.2 vs previous 14 d
Sleep quality
Wearable29.3/100
worsening · -3.9 vs previous 14 d
Libido
Daily log2.4/10
worsening · -0.4 vs previous 14 d
HRV
Wearable34.9 ms
worsening · -3.1 vs previous 14 d
Toxicity
Blood49.2/100
worsening · +7.7 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 41 from the failing basin, 49 from restoration.
Would help
- GI-04 GI Support Protocol74% improved among 35 similar · onset 8 d · confidence 58%
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 63%
- DT-01 Dosing / Timing Recommendation83% improved among 12 similar · onset 5 d · confidence 63%
- More proteinGI -6 next day on high-intake days · n 21
Would not help
- AD-05 Adherence Supportonly 11% improved among 9 similar
- Keep caffeine lowGI +6.1 next day on high-intake days · n 17
- Keep fat lowGI +5.9 next day on high-intake days · n 19
- Keep histamine lowGI +5.3 next day on high-intake days · n 20
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Caffeine+6.1detractor · 95%
- Protein-6supporter · 95%
- Dietary fat load+5.9detractor · 95%
- Histamine load+5.3detractor · 95%
- Lactose+1.4no signal · 23%
- Alcohol+0.8no signal · 17%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 35/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 49
- Mucosal barrier integrity ↓50
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 52 and rising
- Inflammatory signalling ↓40
- BloodInflammatory load index 50
- WearableHRV 35 ms, trending down
- Autonomic recovery ↓20
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 3 · butyrate capacity 35/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 37 ms
- Sleep
- 6.1 h
- Steps
- 7,249
- Resting HR
- 67 bpm
Daily log: GI score 52, nutritional resilience 47, adherence 69.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03031 | 41% | S16 | CR-01 | improved | 49 |
| P-03382 | 41% | S01 | GI-04 | improved | 56 |
| P-03225 | 40% | S19 | GI-04 | improved | 50 |
| P-03379 | 40% | S12 | GI-04 | improved | 51 |
| P-03465 | 37% | S17 | CR-01 | improved | 65 |
| P-03201 | 36% | S15 | GI-04 | improved | 68 |
| P-03099 | 34% | S17 | CR-01 | improved | 55 |
| P-03103 | 34% | S14 | GI-04 | improved | 63 |
| P-03166 | 34% | S20 | CR-01 | improved | 62 |
| P-03191 | 33% | S19 | GI-04 | improved | 51 |
| P-03226 | 33% | S05 | GI-04 | improved | 43 |
| P-03365 | 33% | S14 | NP-02 | improved | 46 |