Patient P-03037
Therapy response
Declining
Tolerance
Stable
GI state
Unstable
Inflammatory state
Stable
Nutritional resilience
Unstable
Discontinuation risk
87%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 39 NP-02 recommended — Dietary Support Protocol NP-02
- Day 40 Patient accepted — Started NP-02 in the companion
- Day 50 GI symptom burden −23% vs expected — Dietary Support Protocol NP-02
- Day 56 Tolerance state changed — Unstable → Improving
- Day 63 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 63 GI-04 recommended — GI Support Protocol GI-04
- Day 64 Patient accepted — Started GI-04 in the companion
- Day 72 No meaningful change — GI Support Protocol GI-04
What changed?
Trajectory began diverging from predicted response on Day 63.
Primary contributors, last 14 days
- GI instability+9
- Nutritional resilience-4
- Treatment adherence-4
What helped?
- Dietary Support Protocol NP-02Day 39Result: symptom burden −23%
- GI Support Protocol GI-04Day 63Result: no meaningful change
LIFE OS recommendation
Supportive Compound SC-12
78%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 88% showed improvement
- median effect visible after 6 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log2.2/10
worsening · -0.3 vs previous 14 d
Stress level
Daily log6.5/10
worsening · +0.3 vs previous 14 d
Pessimism score
Daily log6.2/10
worsening · +0.3 vs previous 14 d
Sleep quality
Wearable45.2/100
improving · +3.4 vs previous 14 d
Libido
Daily log2.8/10
worsening · -0.5 vs previous 14 d
HRV
Wearable39 ms
stable · +0.1 vs previous 14 d
Toxicity
Blood43.2/100
worsening · +6.4 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 23 from the failing basin, 69 from restoration.
Would help
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 75%
- SC-12 Supportive Compound89% improved among 9 similar · onset 6 d · confidence 75%
- DT-01 Dosing / Timing Recommendation63% improved among 8 similar · onset 5 d · confidence 75%
- More proteinGI -3.8 next day on high-intake days · n 17
- More histamineGI -1.9 next day on high-intake days · n 20
Would not help
- GI-04 GI Support Protocolalready tried, no meaningful change
- AD-05 Adherence Supportonly 30% improved among 10 similar
- Keep caffeine lowGI +3.6 next day on high-intake days · n 16
- Keep fat lowGI +3.3 next day on high-intake days · n 22
- Keep lactose lowGI +3.3 next day on high-intake days · n 24
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-3.8supporter · 95%
- Caffeine+3.6detractor · 95%
- Dietary fat load+3.3detractor · 95%
- Lactose+3.3detractor · 95%
- Histamine load-1.9supporter · 63%
- Alcohol-0.6no signal · 19%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Drug metabolism and exposure ↑95
- DNACYP2D6 poor metabolizer → higher exposure
- DNADPYD *2A → slower clearance
- BloodToxicity index 43
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 33/100
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 57
- Autonomic recovery ↓45
- WearableResting HR 77 bpm
- Wearable2,020 steps/day
- Mucosal barrier integrity ↓20
- Daily logGI symptom score 66 and rising
DNA
Fictional pharmacogenomic panel
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 2.2 · butyrate capacity 33/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 39 ms
- Sleep
- 6.7 h
- Steps
- 3,011
- Resting HR
- 79 bpm
Daily log: GI score 66, nutritional resilience 39, adherence 38.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.