Patient P-03120
Therapy response
Favorable
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
81%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 95 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 95.
Primary contributors, last 14 days
- Inflammatory activity+21
- GI instability+20
- Nutritional resilience-16
- Toxicity+15
- Treatment adherence-5
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
67%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log2.5/10
worsening · -1.5 vs previous 14 d
Stress level
Daily log7.1/10
worsening · +1.4 vs previous 14 d
Pessimism score
Daily log5.8/10
worsening · +0.8 vs previous 14 d
Sleep quality
Wearable22.5/100
worsening · -14.1 vs previous 14 d
Libido
Daily log2.1/10
worsening · -0.9 vs previous 14 d
HRV
Wearable40 ms
worsening · -4.9 vs previous 14 d
Toxicity
Blood41.1/100
worsening · +6.2 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 38 from the failing basin, 60 from restoration.
Would help
- GI-04 GI Support Protocol74% improved among 34 similar · onset 8 d · confidence 66%
- ME-01 Monitoring Escalation100% improved among 10 similar · onset 3 d · confidence 75%
- DT-01 Dosing / Timing Recommendation83% improved among 12 similar · onset 5 d · confidence 75%
- More proteinGI -4.8 next day on high-intake days · n 22
Would not help
- AD-05 Adherence Supportonly 25% improved among 8 similar
- Keep histamine lowGI +4.9 next day on high-intake days · n 25
- Keep fat lowGI +4.2 next day on high-intake days · n 24
- Keep lactose lowGI +3.5 next day on high-intake days · n 20
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+4.9detractor · 95%
- Protein-4.8supporter · 95%
- Dietary fat load+4.2detractor · 95%
- Lactose+3.5detractor · 95%
- Caffeine-1.2no signal · 25%
- Alcohol+1no signal · 22%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 61 and rising
- WearableSleep 5.8 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 27/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 61
- Autonomic recovery ↓65
- WearableResting HR 86 bpm
- Wearable612 steps/day
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 41
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 1.8 · butyrate capacity 27/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 46 ms
- Sleep
- 6.8 h
- Steps
- 1,848
- Resting HR
- 83 bpm
Daily log: GI score 61, nutritional resilience 40, adherence 85.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.