Patient P-03143
Therapy response
Declining
Tolerance
Improving
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Favorable
Discontinuation risk
7%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S11
- Day 15 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 18 DT-01 recommended — Dosing / Timing Recommendation DT-01
- Day 19 Patient accepted — Started DT-01 in the companion
- Day 24 GI symptom burden −16% vs expected — Dosing / Timing Recommendation DT-01
- Day 30 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 15.
Primary contributors, last 14 days
- Inflammatory activity-11
- GI instability-10
- Toxicity-8
- Treatment adherence-7
- Nutritional resilience-2
What helped?
- Dosing / Timing Recommendation DT-01Day 18Result: symptom burden −16%
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log6/10
worsening · -0.5 vs previous 14 d
Stress level
Daily log3.2/10
worsening · +0.2 vs previous 14 d
Pessimism score
Daily log3.2/10
worsening · +0.3 vs previous 14 d
Sleep quality
Wearable66.2/100
worsening · -2.6 vs previous 14 d
Libido
Daily log5.7/10
worsening · -0.2 vs previous 14 d
HRV
Wearable59.1 ms
stable · -0.3 vs previous 14 d
Toxicity
Blood12.6/100
worsening · +7.0 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 80 from the failing basin, 30 from restoration.
Would help
- No untried action with strong evidence. Compose one from primitives.
- More proteinGI -5.8 next day on high-intake days · n 21
Would not help
- AD-05 Adherence Supportonly 33% improved among 15 similar
- Keep lactose lowGI +4.4 next day on high-intake days · n 17
- Keep fat lowGI +3.3 next day on high-intake days · n 20
- Keep alcohol lowGI +2.4 next day on high-intake days · n 16
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-5.8supporter · 95%
- Lactose+4.4detractor · 95%
- Dietary fat load+3.3detractor · 92%
- Alcohol+2.4detractor · 59%
- Histamine load-1.5no signal · 33%
- Caffeine+1.4no signal · 31%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 36/100
- MicrobiomeF. prausnitzii depleted
- Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
- Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
- Inflammatory signalling ↓20
- MicrobiomeBacteroides fragilis expansion
DNA
Fictional pharmacogenomic panel
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.8 · butyrate capacity 36/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 57 ms
- Sleep
- 7.1 h
- Steps
- 3,195
- Resting HR
- 72 bpm
Daily log: GI score 11, nutritional resilience 70, adherence 93.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.