Patient P-03193
Therapy response
Stable
Tolerance
Favorable
GI state
Deteriorating
Inflammatory state
Favorable
Nutritional resilience
Favorable
Discontinuation risk
21%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S13
- Day 14 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 18 DT-01 recommended — Dosing / Timing Recommendation DT-01
- Day 19 Patient accepted — Started DT-01 in the companion
- Day 24 GI symptom burden −17% vs expected — Dosing / Timing Recommendation DT-01
- Day 30 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 14.
Primary contributors, last 14 days
- GI instability+8
- Nutritional resilience+2
What helped?
- Dosing / Timing Recommendation DT-01Day 18Result: symptom burden −17%
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients.
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Autonomic recovery ↑45
- WearableResting HR 74 bpm
- Wearable3,668 steps/day
- Butyrate / short-chain fatty acid production ↓35
- MicrobiomeButyrate capacity 44/100
- Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
- Inflammatory signalling ↓20
- MicrobiomeBacteroides fragilis expansion
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.7 · butyrate capacity 44/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 68 ms
- Sleep
- 7.0 h
- Steps
- 3,251
- Resting HR
- 72 bpm
Daily log: GI score 18, nutritional resilience 64, adherence 100.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03408 | 56% | S09 | HY-01 | improved | 53 |
| P-03067 | 51% | S06 | DT-01 | no change | 50 |
| P-03442 | 50% | S11 | DT-01 | improved | 51 |
| P-03339 | 49% | S19 | — | — | 49 |
| P-03062 | 48% | S11 | — | — | 44 |
| P-03167 | 48% | S18 | — | — | 53 |
| P-03203 | 47% | S10 | — | — | 56 |
| P-03097 | 46% | S16 | — | — | 60 |
| P-03114 | 46% | S11 | DT-01 | improved | 48 |
| P-03375 | 46% | S09 | DT-01 | improved | 52 |
| P-03040 | 45% | S03 | — | — | 51 |
| P-03143 | 45% | S11 | DT-01 | improved | 49 |