Patient P-03114
Therapy response
Stable
Tolerance
Improving
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Improving
Discontinuation risk
6%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S11
- Day 13 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 18 DT-01 recommended — Dosing / Timing Recommendation DT-01
- Day 19 Patient accepted — Started DT-01 in the companion
- Day 24 GI symptom burden −24% vs expected — Dosing / Timing Recommendation DT-01
- Day 30 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 13.
Primary contributors, last 14 days
- GI instability-12
- Nutritional resilience+10
- Toxicity-9
- Inflammatory activity-6
What helped?
- Dosing / Timing Recommendation DT-01Day 18Result: symptom burden −24%
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients.
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Drug metabolism and exposure ↑75
- DNACYP2D6 poor metabolizer → higher exposure
- DNADPYD *2A → slower clearance
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 37/100
- MicrobiomeF. prausnitzii depleted
- Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
- Inflammatory signalling ↓20
- MicrobiomeBacteroides fragilis expansion
DNA
Fictional pharmacogenomic panel
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.4 · butyrate capacity 37/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 69 ms
- Sleep
- 7.0 h
- Steps
- 4,504
- Resting HR
- 72 bpm
Daily log: GI score 13, nutritional resilience 73, adherence 93.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03062 | 56% | S11 | — | — | 44 |
| P-03143 | 54% | S11 | DT-01 | improved | 49 |
| P-03442 | 53% | S11 | DT-01 | improved | 51 |
| P-03408 | 51% | S09 | HY-01 | improved | 53 |
| P-03268 | 47% | S15 | DT-01 | improved | 56 |
| P-03339 | 47% | S19 | — | — | 49 |
| P-03167 | 46% | S18 | — | — | 53 |
| P-03193 | 46% | S13 | DT-01 | improved | 53 |
| P-03475 | 45% | S20 | HY-01 | improved | 50 |
| P-03067 | 44% | S06 | DT-01 | no change | 50 |
| P-03392 | 44% | S15 | GI-04 | improved | 52 |
| P-03244 | 42% | S08 | DT-01 | improved | 53 |