Patient P-03271
Therapy response
Declining
Tolerance
Improving
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
53%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S19
- Day 94 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 94.
Primary contributors, last 14 days
- Toxicity-6
- Inflammatory activity+3
- Treatment adherence+2
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
59%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 80% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log3.4/10
worsening · -0.1 vs previous 14 d
Stress level
Daily log6.8/10
worsening · +0.3 vs previous 14 d
Pessimism score
Daily log5.2/10
worsening · +0.5 vs previous 14 d
Sleep quality
Wearable34.8/100
worsening · -3.6 vs previous 14 d
Libido
Daily log2.9/10
stable · -0.1 vs previous 14 d
HRV
Wearable48.4 ms
worsening · -3.5 vs previous 14 d
Toxicity
Blood44.3/100
improving · -4.8 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 44 from the failing basin, 58 from restoration.
Would help
- GI-04 GI Support Protocol71% improved among 35 similar · onset 8 d · confidence 59%
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 61%
- DT-01 Dosing / Timing Recommendation90% improved among 10 similar · onset 5 d · confidence 61%
- More proteinGI -4.7 next day on high-intake days · n 15
- More caffeineGI -2.3 next day on high-intake days · n 20
Would not help
- Keep histamine lowGI +3.1 next day on high-intake days · n 21
- Keep fat lowGI +2.8 next day on high-intake days · n 21
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-4.7supporter · 95%
- Histamine load+3.1detractor · 88%
- Dietary fat load+2.8detractor · 74%
- Caffeine-2.3supporter · 56%
- Alcohol+0.9no signal · 21%
- Lactose-0.1no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 42/100
- Daily logFibre intake low in recent food logs
- Drug metabolism and exposure ↑55
- DNADPYD *2A → slower clearance
- BloodToxicity index 44
- Mucosal barrier integrity ↓50
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 60 and rising
- Inflammatory signalling ↑50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 60
- Autonomic recovery ↑25
- WearableResting HR 73 bpm
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Intermediate metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.1 · butyrate capacity 42/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 47 ms
- Sleep
- 6.1 h
- Steps
- 4,100
- Resting HR
- 75 bpm
Daily log: GI score 60, nutritional resilience 35, adherence 69.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.