Patient P-03285
Therapy response
Stable
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
94%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S04
- Day 85 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 85.
Primary contributors, last 14 days
- GI instability+30
- Inflammatory activity+20
- Treatment adherence-14
- Nutritional resilience-7
- Toxicity+6
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
62%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 83% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log2.2/10
worsening · -1.3 vs previous 14 d
Stress level
Daily log6.4/10
worsening · +1.2 vs previous 14 d
Pessimism score
Daily log5.2/10
worsening · +0.9 vs previous 14 d
Sleep quality
Wearable28.6/100
worsening · -9.7 vs previous 14 d
Libido
Daily log2.9/10
worsening · -0.8 vs previous 14 d
HRV
Wearable42.6 ms
worsening · -6.2 vs previous 14 d
Toxicity
Blood42.9/100
worsening · +9.0 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 31 from the failing basin, 73 from restoration.
Would help
- GI-04 GI Support Protocol74% improved among 35 similar · onset 8 d · confidence 60%
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 70%
- DT-01 Dosing / Timing Recommendation83% improved among 12 similar · onset 5 d · confidence 70%
- More proteinGI -4.6 next day on high-intake days · n 15
Would not help
- AD-05 Adherence Supportonly 22% improved among 9 similar
- Keep histamine lowGI +4.8 next day on high-intake days · n 21
- Keep fat lowGI +2.7 next day on high-intake days · n 24
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+4.8detractor · 95%
- Protein-4.6supporter · 95%
- Dietary fat load+2.7detractor · 88%
- Lactose+1.7no signal · 52%
- Alcohol-0.8no signal · 25%
- Caffeine-0.4no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 73 and rising
- WearableSleep 5.7 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 43/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↓45
- WearableResting HR 73 bpm
- WearableShort sleep window
- Inflammatory signalling ↑25
- BloodInflammatory load index 63
- Drug metabolism and exposure ↑20
- BloodToxicity index 43
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Intermediate metabolizerExpected exposure
Microbiome
Shannon diversity 1.9 · butyrate capacity 43/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 47 ms
- Sleep
- 5.4 h
- Steps
- 7,382
- Resting HR
- 69 bpm
Daily log: GI score 73, nutritional resilience 40, adherence 73.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03379 | 45% | S12 | GI-04 | improved | 51 |
| P-03225 | 42% | S19 | GI-04 | improved | 50 |
| P-03099 | 37% | S17 | CR-01 | improved | 55 |
| P-03031 | 36% | S16 | CR-01 | improved | 49 |
| P-03382 | 36% | S01 | GI-04 | improved | 56 |
| P-03465 | 35% | S17 | CR-01 | improved | 65 |
| P-03166 | 34% | S20 | CR-01 | improved | 62 |
| P-03201 | 34% | S15 | GI-04 | improved | 68 |
| P-03145 | 33% | S14 | GI-04 | improved | 51 |
| P-03346 | 33% | S17 | GI-04 | improved | 71 |
| P-03070 | 32% | S14 | GI-04 | improved | 51 |
| P-03090 | 32% | S02 | GI-04 | improved | 48 |