Patient P-03293
Therapy response
Unstable
Tolerance
Deteriorating
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
78%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 54 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 69 GI-04 recommended — GI Support Protocol GI-04
- Day 70 Patient accepted — Started GI-04 in the companion
- Day 78 No meaningful change — GI Support Protocol GI-04
What changed?
Trajectory began diverging from predicted response on Day 54.
Primary contributors, last 14 days
- Toxicity+16
- Treatment adherence+8
- Inflammatory activity+5
- GI instability-2
What helped?
- GI Support Protocol GI-04Day 69Result: no meaningful change
LIFE OS recommendation
Dosing / Timing Recommendation DT-01
70%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 80% showed improvement
- median effect visible after 5 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log2.6/10
improving · +0.1 vs previous 14 d
Stress level
Daily log7.3/10
stable · -0.1 vs previous 14 d
Pessimism score
Daily log7.2/10
stable · -0.0 vs previous 14 d
Sleep quality
Wearable32/100
worsening · -3.0 vs previous 14 d
Libido
Daily log1.8/10
improving · +0.3 vs previous 14 d
HRV
Wearable45.3 ms
stable · +1.1 vs previous 14 d
Toxicity
Blood49.3/100
improving · -7.0 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 19 from the failing basin, 75 from restoration.
Would help
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 72%
- SC-12 Supportive Compound100% improved among 8 similar · onset 6 d · confidence 72%
- DT-01 Dosing / Timing Recommendation80% improved among 10 similar · onset 5 d · confidence 72%
- More proteinGI -5.3 next day on high-intake days · n 23
Would not help
- GI-04 GI Support Protocolalready tried, no meaningful change
- AD-05 Adherence Supportonly 18% improved among 11 similar
- Keep histamine lowGI +5.5 next day on high-intake days · n 17
- Keep alcohol lowGI +4.3 next day on high-intake days · n 19
- Keep fat lowGI +4.2 next day on high-intake days · n 19
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+5.5detractor · 95%
- Protein-5.3supporter · 95%
- Alcohol+4.3detractor · 95%
- Dietary fat load+4.2detractor · 95%
- Lactose+4.2detractor · 95%
- Caffeine+4detractor · 95%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↑70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 61
- Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 49
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 27/100
- Daily logFibre intake low in recent food logs
- Mucosal barrier integrity ↓50
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 70 and rising
- Autonomic recovery ↑45
- WearableResting HR 79 bpm
- Wearable919 steps/day
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 2.1 · butyrate capacity 27/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 46 ms
- Sleep
- 6.6 h
- Steps
- 1,753
- Resting HR
- 76 bpm
Daily log: GI score 70, nutritional resilience 33, adherence 49.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.