Patient P-03351
Therapy response
Improving
Tolerance
Deteriorating
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Favorable
Discontinuation risk
21%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S07
- Day 90 AD-05 recommended — Adherence Support AD-05
- Day 91 Patient accepted — Started AD-05 in the companion
- Day 96 No meaningful change — Adherence Support AD-05
- Day 101 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 101.
Primary contributors, last 14 days
- Toxicity+12
- Treatment adherence-9
- Inflammatory activity-6
- GI instability-4
- Nutritional resilience-2
What helped?
- Adherence Support AD-05Day 90Result: no meaningful change
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients.
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
- Inflammatory signalling ↓25
- DNAIL6 -174 variant raises baseline inflammatory tone
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
- Autonomic recovery ↑20
- WearableShort sleep window
- Mucosal barrier integrity ↓10
- WearableSleep 5.7 h, below personal baseline
DNA
Fictional pharmacogenomic panel
- IL6 -174 G/CHigher inflammatory tone
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Intermediate metabolizerExpected exposure
Microbiome
Shannon diversity 3.2 · butyrate capacity 60/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 70 ms
- Sleep
- 6.8 h
- Steps
- 6,233
- Resting HR
- 63 bpm
Daily log: GI score 25, nutritional resilience 60, adherence 82.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03204 | 47% | S16 | AD-05 | improved | 48 |
| P-03117 | 43% | S05 | — | — | 35 |
| P-03375 | 42% | S09 | DT-01 | improved | 52 |
| P-03339 | 41% | S19 | — | — | 49 |
| P-03362 | 41% | S20 | — | — | 42 |
| P-03441 | 41% | S19 | AD-05 | improved | 37 |
| P-03036 | 40% | S11 | — | — | 53 |
| P-03068 | 39% | S06 | — | — | 61 |
| P-03153 | 39% | S12 | BR-03 | no change | 40 |
| P-03167 | 39% | S18 | — | — | 53 |
| P-03209 | 39% | S03 | — | — | 58 |
| P-03245 | 39% | S02 | — | — | 57 |